{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:10:04Z","timestamp":1756311004802,"version":"3.44.0"},"reference-count":36,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,10,17]]},"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Sulfonamides have been related to drug-induced acute angle closure of the eye, but scarce reports exist concerning furosemide. We describe the second case of acute chamber narrowing (ACN) during furosemide exposure. A 65-year-old man with a renal transplant presented with ACN, after 3\u2009months of furosemide intake. Finally, the patient required a bilateral iridotomy and right lens replacement. ACN has been associated with drugs containing sulfonamide derivatives, but an evaluation with pharmacovigilance scales for adverse drug reaction (ADR)-standardised causality assessment has not been provided. We use this case to illustrate how medicines and an ADR should be evaluated and reported. The spreading of pharmacovigilance information on what should be a rare and unexpected condition related to a drug could mean that other reports emerge about ADR with this drug and regulatory agencies perform consequently, as happened with topiramate.<\/jats:p>","DOI":"10.1136\/bcr-2021-244581","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T12:10:18Z","timestamp":1643112618000},"page":"e244581","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Application of pharmacovigilance tools in a case of subacute anterior angle narrowing while under furosemide exposure"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3044-7973","authenticated-orcid":false,"given":"Emilie","family":"Anderssen-Nordahl","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Vall d'Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Barcelona, Catalunya, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-0218","authenticated-orcid":false,"given":"Judit","family":"Riera-Arnau","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Vall d'Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Barcelona, Catalunya, Spain"},{"name":"Immune Mediated Diseases and Innovative Therapies Research Group, Vall d\u2019Hebron Institut de Recerca (VHIR), Vall d\u2019Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Perell\u00f3 Carrascosa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Vall d'Hebron Hospital Universitari, Vall d\u2019Hebron Barcelona Hospital Campus, Barcelona, Catalunya, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"G\u00f3mez Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Institut Catal\u00e0 de la Retina (ICR), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"2025082708532689000_15.1.e244581.1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5005\/jp-journals-10078-1261","article-title":"Drug-induced acute angle-closure glaucoma: a review","volume":"13","author":"Yang","year":"2019","journal-title":"J Curr Glaucoma Pract"},{"key":"2025082708532689000_15.1.e244581.2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/S0161-6420(89)32759-X","article-title":"Association of systemic hypertension and diabetes mellitus with cataract extraction","volume":"96","author":"Szmyd","year":"1989","journal-title":"Ophthalmology"},{"key":"2025082708532689000_15.1.e244581.3","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1097\/OPX.0000000000000475","article-title":"Zonisamide-induced angle closure and myopic shift","volume":"92","author":"Weiler","year":"2015","journal-title":"Optom Vis Sci"},{"key":"2025082708532689000_15.1.e244581.4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00347-020-01091-9","article-title":"[Bilateral effusion syndrome induced by chlorthalidon]","volume":"118","author":"Winter","year":"2021","journal-title":"Ophthalmologe"},{"key":"2025082708532689000_15.1.e244581.5","doi-asserted-by":"crossref","DOI":"10.4103\/0301-4738.62657","article-title":"Bilateral simultaneous acute angle closure caused by sulphonamide derivatives: a case series","volume":"58","author":"Senthil","year":"2010","journal-title":"Indian J Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.6","first-page":"2116","article-title":"Sulfonamide hypersensitivity: fact and fiction","volume":"7","author":"Khan","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"2025082708532689000_15.1.e244581.7","unstructured":"Trastornos de la refracci\u00f3n Y de la acomodaci\u00f3n POR f\u00e1rmacos. health department from the Generalitat de Catalunya. Butll Farm Cat 2017;15. [Epub ahead of print: Available at] https:\/\/scientiasalut.gencat.cat\/bitstream\/handle\/11351\/2935\/BFV_2017_15_02_cas.pdf?sequence=2&isAllowed=y"},{"key":"2025082708532689000_15.1.e244581.8","unstructured":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios (AEMPS) . Medicinal products for human use. Ministerio de Sanidad (Madrid), Gobierno de Espa\u00f1a, 2020. Available: https:\/\/www.aemps.gob.es\/ [Accessed Last access: 19th May 2021]."},{"key":"2025082708532689000_15.1.e244581.9","doi-asserted-by":"crossref","first-page":"e748","DOI":"10.1097\/IJG.0000000000000430","article-title":"Presumed furosemide-associated bilateral angle-closure glaucoma","volume":"25","author":"Boundaoui","year":"2016","journal-title":"J Glaucoma"},{"key":"2025082708532689000_15.1.e244581.10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(69)91241-0"},{"key":"2025082708532689000_15.1.e244581.11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.medcli.2016.06.012","article-title":"[Causality assessment in reports on adverse drug reactions. algorithm of Spanish pharmacovigilance system]","volume":"147","author":"Aguirre","year":"2016","journal-title":"Med Clin"},{"key":"2025082708532689000_15.1.e244581.12","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"2025082708532689000_15.1.e244581.13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0886-3350(88)80065-8","article-title":"Cataracts in dunedin program participants: an evaluation of risk factors","volume":"14","author":"Marks","year":"1988","journal-title":"J Cataract Refract Surg"},{"key":"2025082708532689000_15.1.e244581.14","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/eye.2014.180","article-title":"Short-Term intraocular pressure trends following intravitreal ranibizumab injections for neovascular age-related macular degeneration\u2014the role of oral acetazolamide in protecting glaucoma patients","volume":"28","author":"Murray","year":"2014","journal-title":"Eye"},{"key":"2025082708532689000_15.1.e244581.15","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2415-13-58","article-title":"Indapamide-induced transient myopia with supraciliary effusion: case report","volume":"13","author":"V\u00e9gh","year":"2013","journal-title":"BMC Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.16","unstructured":"VigiAccess\u00a9, Uppsala Monitoring Centre . World Health Organization\u2019s (WHO) global database of adverse drug reactions. Available: http:\/\/www.vigiaccess.org\/ [Accessed 19 May 2021]."},{"key":"2025082708532689000_15.1.e244581.17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0002-9394(14)73654-2","article-title":"Transient myopia, angle-closure glaucoma, and choroidal detachment after oral acetazolamide","volume":"115","author":"Fan","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.oftal.2016.03.013","article-title":"Reacci\u00f3n ocular adversa a la acetazolamida: a prop\u00f3sito de un caso","volume":"91","author":"Llovet-Rausell","year":"2016","journal-title":"Arch Soc Esp Oftalmol"},{"key":"2025082708532689000_15.1.e244581.19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jcrs.2010.12.032","article-title":"Acute bilateral angle-closure glaucoma and choroidal effusion associated with acetazolamide administration after cataract surgery","volume":"37","author":"Mancino","year":"2011","journal-title":"J Cataract Refract Surg"},{"key":"2025082708532689000_15.1.e244581.20","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1755-3768.1963.tb03567.x","article-title":"Hygroton-induced myopia and retinal edema","volume":"41","author":"Ericson","year":"1963","journal-title":"Acta Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/IJG.0000000000000037","article-title":"Uveal effusion as a mechanism of bilateral angle-closure glaucoma induced by chlorthalidone","volume":"24","author":"Singer","year":"2015","journal-title":"J Glaucoma"},{"key":"2025082708532689000_15.1.e244581.22","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1961.01840020214009"},{"key":"2025082708532689000_15.1.e244581.23","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-206690"},{"key":"2025082708532689000_15.1.e244581.24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3341\/kjo.2011.25.3.214","article-title":"Acute-onset bilateral myopia and ciliochoroidal effusion induced by hydrochlorothiazide","volume":"25","author":"Roh","year":"2011","journal-title":"Korean J Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0002-9394(99)00402-X","article-title":"Acute transient myopia induced by indapamide","volume":"129","author":"Blain","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.26","first-page":"1","article-title":"Bilateral angle narrowing and acute myopia induced by indapamide: a case report","volume":"2018","author":"Pedrosa","year":"2018","journal-title":"Case Rep Ophthalmol Med"},{"key":"2025082708532689000_15.1.e244581.27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2147\/OPTH.S41540","article-title":"Acute bilateral angle closure glaucoma induced by methazolamide","volume":"7","author":"Aref","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10384-012-0159-y","article-title":"Bilateral transient myopia, angle-closure glaucoma, and choroidal detachment induced by methazolamide","volume":"56","author":"Kwon","year":"2012","journal-title":"Jpn J Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.29","doi-asserted-by":"crossref","first-page":"117954761985538","DOI":"10.1177\/1179547619855388","article-title":"Bilateral transient myopia with sulfasalazine treatment","volume":"12","author":"Paz","year":"2019","journal-title":"Clin Med Insights Case Rep"},{"key":"2025082708532689000_15.1.e244581.30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1475-1313.2003.00136.x"},{"key":"2025082708532689000_15.1.e244581.31","doi-asserted-by":"crossref","DOI":"10.1186\/s12886-020-01635-2","article-title":"Acute bilateral myopia induced by triplixam: a case report","volume":"20","author":"Jaruseviciene","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.04.004"},{"key":"2025082708532689000_15.1.e244581.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.01.021"},{"key":"2025082708532689000_15.1.e244581.34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2006.01365.x"},{"key":"2025082708532689000_15.1.e244581.35","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0002-9394(14)72174-9","article-title":"Choroidal effusion as a mechanism for transient myopia induced by hydrochlorothiazide and triamterene","volume":"120","author":"S\u00f6ylev","year":"1995","journal-title":"Am J Ophthalmol"},{"key":"2025082708532689000_15.1.e244581.36","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-013-9793-8"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-244581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:53:38Z","timestamp":1756310018000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-244581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,25]]},"published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1136\/bcr-2021-244581"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-244581","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}