{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:47:37Z","timestamp":1756896457428,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,12,31]]},"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>A man in his 20s presented with diminished vision in the left eye. He had a history of Pott\u2019s spine and had been diagnosed elsewhere as having left eye tubercular granuloma in the retina. He was started on anti-tubercular therapy and high-dose oral steroids. He presented to us 1\u2009month later. Presently fundus examination revealed a yellow to whitish mass temporal to disc with diffuse hard exudates throughout the retina. Swept-source optical coherence tomography (SSOCT) revealed a hyper-reflective mass involving the retina. SSOCT angiography and fundus fluorescein angiography revealed vascularity within the lesion. We made a diagnosis of a secondary reactive retinal astrocytic vasoproliferative tumour (VPT) and hence tapered the steroids and given intravitreal bevacizumab injection. At 6 weeks follow-up after intravitreal bevacizumab, there was some amount of resolution of hard exudates along with reduction of the vascular pattern of the lesion. The peripapillary location and development of a VPT following resolution of a presumed tubercular granuloma is rare.<\/jats:p>","DOI":"10.1136\/bcr-2021-244642","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T10:05:42Z","timestamp":1673345142000},"page":"e244642","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal imaging of reactive retinal astrocytic vasoproliferative tumour in a case of systemic tuberculosis"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-2608","authenticated-orcid":false,"given":"Sindhuja","family":"Kandasamy","sequence":"first","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Chawla","sequence":"additional","affiliation":[{"name":"Ophthalmology, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"2025082803360610000_16.1.e244642.1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ajo.2013.03.016","article-title":"Reactive retinal astrocytic tumors (so-called vasoproliferative tumors): histopathologic, immunohistochemical, and genetic studies of four cases","volume":"156","author":"Shields","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"2025082803360610000_16.1.e244642.2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/bjo.2005.086066","article-title":"Vasoproliferative retinal tumour","volume":"90","author":"Damato","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"2025082803360610000_16.1.e244642.3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/ijo.IJO_128_18","article-title":"Retinal vasoproliferative tumor - A proposal for classification","volume":"66","author":"Honavar","year":"2018","journal-title":"Indian J Ophthalmol"},{"key":"2025082803360610000_16.1.e244642.4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1590\/S0004-27492007000300025","article-title":"[Vasoproliferative tumor associated with presumed ocular tuberculosis: case report]","volume":"70","author":"Rodrigues","year":"2007","journal-title":"Arq Bras Oftalmol"},{"key":"2025082803360610000_16.1.e244642.5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100050083035"},{"key":"2025082803360610000_16.1.e244642.6","doi-asserted-by":"crossref","DOI":"10.1001\/2013.jamaophthalmol.524","article-title":"Retinal vasoproliferative tumors: comparative clinical features of primary vs secondary tumors in 334 cases","volume":"131","author":"Shields","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"2025082803360610000_16.1.e244642.7","doi-asserted-by":"crossref","first-page":"100827","DOI":"10.1016\/j.ajoc.2020.100827","article-title":"Optic nerve head reactive retinal astrocytic tumor treated with photodynamic therapy","volume":"19","author":"Onishi","year":"2020","journal-title":"Am J Ophthalmol Case Rep"},{"key":"2025082803360610000_16.1.e244642.8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/eye.2014.113","article-title":"Intravitreal bevacizumab in the treatment of vasoproliferative retinal tumours","volume":"28","author":"Rogers","year":"2014","journal-title":"Eye"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-244642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:36:14Z","timestamp":1756377374000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-244642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,10]]},"published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1136\/bcr-2021-244642"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-244642","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}