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Recurrent implantable cardioverter defibrillator (ICD) shocks occurred for ventricular tachycardia (VT) and ventricular fibrillation (VF) as well as inappropriate shocks as a result of rapidly conducted atrial fibrillation (AF). Catheter ablation was effective in controlling these episodes of AF. Despite left cardiac sympathetic denervation, episodes of ventricular arrhythmia and subsequent ICD shocks persisted. Contralateral sympathetic cardiac denervation was subsequently undertaken, with histology suggesting T-cell mediated ganglionitis. 18 months on, there have been no further episodes of ventricular arrhythmia.<\/jats:p>","DOI":"10.1136\/bcr-2021-244710","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T22:24:44Z","timestamp":1644877484000},"page":"e244710","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral cardiac sympathetic denervation for refractory arrhythmia in an individual with catecholaminergic polymorphic ventricular tachycardia associated with T-cell-mediated ganglionitis"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3650-1897","authenticated-orcid":false,"given":"Alexander","family":"Carpenter","sequence":"first","affiliation":[{"name":"Bristol Heart Institute, Bristol, UK"},{"name":"University of Bristol, Bristol, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-5258","authenticated-orcid":false,"given":"Georgia May","family":"Connolly","sequence":"additional","affiliation":[{"name":"Bristol Heart Institute, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Duncan","sequence":"additional","affiliation":[{"name":"Bristol Heart Institute, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Nisbet","sequence":"additional","affiliation":[{"name":"Bristol Heart Institute, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"2025082722103877000_15.2.e244710.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226845"},{"key":"2025082722103877000_15.2.e244710.2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00390.2009"},{"key":"2025082722103877000_15.2.e244710.3","first-page":"193","article-title":"Traitment chirurgical de I\u2019 angine de poitrine par la resection du sympathetique cervicothoracique","volume":"29","author":"JONNESCO","year":"1921","journal-title":"Press Med"},{"key":"2025082722103877000_15.2.e244710.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197110142851607"},{"key":"2025082722103877000_15.2.e244710.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.03.024"},{"key":"2025082722103877000_15.2.e244710.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015731"},{"key":"2025082722103877000_15.2.e244710.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000125523.14403.1E"},{"key":"2025082722103877000_15.2.e244710.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.5.1389"},{"key":"2025082722103877000_15.2.e244710.9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fcvm.2019.00027","article-title":"Cardiac sympathetic denervation in channelopathies","volume":"6","author":"Dusi","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"2025082722103877000_15.2.e244710.10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90420-3"},{"key":"2025082722103877000_15.2.e244710.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(76)80078-6"},{"key":"2025082722103877000_15.2.e244710.12","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.hrthm.2016.03.014","article-title":"Cardiac sympathetic denervation for intractable ventricular arrhythmias in Chagas disease","volume":"13","author":"Saenz","year":"2016","journal-title":"Heart Rhythm"},{"key":"2025082722103877000_15.2.e244710.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.035"},{"key":"2025082722103877000_15.2.e244710.14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/joa3.12336","article-title":"The effect of bilateral cardiac sympathetic denervation for refractory ventricular tachycardia in ischemic cardiomyopathy","volume":"36","author":"Miki","year":"2020","journal-title":"J Arrhythm"},{"key":"2025082722103877000_15.2.e244710.15","doi-asserted-by":"crossref","DOI":"10.1186\/s13019-019-0838-6","article-title":"Video-Assisted thoracoscopic cardiac denervation of refractory ventricular arrhythmias and electrical storms: a single-center series","volume":"14","author":"T\u00e9llez","year":"2019","journal-title":"J Cardiothorac Surg"},{"key":"2025082722103877000_15.2.e244710.16","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1111\/jocs.15652","article-title":"Bilateral thoracoscopic sympathectomy for cardiac denervation in pediatric population: does Kuntz nerve cauterization have an impact on success?","volume":"36","author":"Ertugrul","year":"2021","journal-title":"J Card Surg"},{"key":"2025082722103877000_15.2.e244710.17","unstructured":"Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias - Full Text View - ClinicalTrials.gov. 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