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We treated her with plasma exchange and later developed bilateral pulmonary embolism, deep venous thrombosis and worsening of weakness. The second set of seven sessions of plasma exchange gave her improvement in muscle strength. However, after a chest infection, another neurological deterioration occurred. The third set of plasma exchanges resulted in excellent response. Nineteen months into her illness she developed a headache followed by left upper limb weakness and focal seizures with left side involvement. Brain imaging revealed a right frontal enhancing lesion that required resection, and biopsy showed diffuse large B-cell lymphoma. She was treated with chemotherapy and whole-brain radiation therapy and remained with left-sided weakness.<\/jats:p>","DOI":"10.1136\/bcr-2021-244767","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T13:21:24Z","timestamp":1635859284000},"page":"e244767","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic inflammatory demyelinating polyneuropathy evolving to primary CNS lymphoma"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-3584","authenticated-orcid":false,"given":"Naim Izet","family":"Kajtazi","sequence":"first","affiliation":[{"name":"Department of Neurology, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehtesham","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ideal Medicare Clinic, Multan, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juman","family":"AlGhamdi","sequence":"additional","affiliation":[{"name":"Medical Imaging Administration, Intervention Neuroradiology, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Altaf","sequence":"additional","affiliation":[{"name":"Department of Hematology, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majed H","family":"AlHameed","sequence":"additional","affiliation":[{"name":"Department of Neurology, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"2025082801380525000_14.11.e244767.1","doi-asserted-by":"publisher","DOI":"10.1177\/014107689408700915"},{"key":"2025082801380525000_14.11.e244767.2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.34.1.42"},{"key":"2025082801380525000_14.11.e244767.3","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20163"},{"key":"2025082801380525000_14.11.e244767.4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.125930"},{"key":"2025082801380525000_14.11.e244767.5","doi-asserted-by":"crossref","unstructured":"Bosch EP , Habermann TM , Tefferi A . 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