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Fine-needle aspiration cytology from the lesion was suggestive of a malignant spindle cell neoplasm, and she underwent its wide local excision. Immunohistochemistry showed expression of epithelial membrane antigen and CD35, but an absence of cytokeratin, desmin, CD23 and S100. The Ki-67 index was low and a diagnosis of FDCS was made. The lack of clinical guidelines was a challenge in the treatment of this rare case. A multidisciplinary board discussion played a critical role in the planning of the patient\u2019s adjuvant treatment.<\/jats:p>","DOI":"10.1136\/bcr-2021-244812","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T11:53:30Z","timestamp":1653306810000},"page":"e244812","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Follicular dendritic cell sarcoma of the thigh: a clinicopathological report and management approach"],"prefix":"10.1136","volume":"15","author":[{"given":"Rajasree","family":"Rajan","sequence":"first","affiliation":[{"name":"Radiation Oncology, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya Gireesan","family":"Roshni","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzann Mary","family":"Mathew","sequence":"additional","affiliation":[{"name":"Pathology, Amrita Institute of Medical Sciences, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Jojo","sequence":"additional","affiliation":[{"name":"Pathology, Amrita Institute of Medical Sciences, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haridas Mohanachandran","family":"Nair","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Amrita Institute of Medical Sciences and Research Centre, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayakumar Dehannathparambil","family":"Kottarathil","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Amrita Institute of Medical Sciences, Cochin, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"2025082722313905000_15.4.e244812.1","article-title":"A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation. 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