{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:43:04Z","timestamp":1762868584760,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,7,31]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>A 62-year-old Caucasian female patient presented with abdominal pain, vomiting and fever 1\u2009day after administration of COVID-19 vaccine. Bloodwork revealed anaemia and thrombocytosis. Abdominal CT angiography showed a mural thrombus at the emergence of the coeliac trunk, hepatic and splenic arteries, and extensive thrombosis of the superior and inferior mesenteric veins, splenic and portal veins, and the inferior vena cava, extending to the left common iliac vein. The spleen displayed extensive areas of infarction. Aetiological investigation included assessment of congenital coagulation disorders and acquired causes with no relevant findings. Administration of COVID-19 vaccine was considered a possible cause of the extensive multifocal thrombosis. After reviewing relevant literature, it was considered that other causes of this event should be further investigated. Thrombosis associated with COVID-19 vaccine is rare and an aetiological relationship should only be considered in the appropriate context and after investigation of other, more frequent, causes.<\/jats:p>","DOI":"10.1136\/bcr-2021-244878","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T13:06:58Z","timestamp":1629119218000},"page":"e244878","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Extensive thrombosis after COVID-19 vaccine: cause or coincidence?"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-1618","authenticated-orcid":false,"given":"Lu\u00eds Louren\u00e7o","family":"Gra\u00e7a","sequence":"first","affiliation":[{"name":"Cardiothoracic Surgery, Centro Hospitalar e Universit\u00e1rio de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-3218","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Amaral","sequence":"additional","affiliation":[{"name":"General Surgery, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ser\u00f4dio","sequence":"additional","affiliation":[{"name":"General Surgery, HBP Unit and Liver transplantation Unit, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Costa","sequence":"additional","affiliation":[{"name":"General Surgery, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"2025082701111514000_14.8.e244878.1","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2019-230145","article-title":"Acute mesenteric ischaemia secondary to portal, splenic and superior mesenteric vein thrombosis","volume":"12","author":"Burch","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2025082701111514000_14.8.e244878.2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0678"},{"key":"2025082701111514000_14.8.e244878.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.709204"},{"key":"2025082701111514000_14.8.e244878.4","doi-asserted-by":"crossref","DOI":"10.1002\/ajh.26272","article-title":"Cerebral venous thrombosis post BNT162b2 mRNA SARS-CoV-2 vaccination: a black Swan event","author":"Fan","year":"2021","journal-title":"Am J Hematol"},{"key":"2025082701111514000_14.8.e244878.5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105906","article-title":"Cerebral venous thrombosis after BNT162b2 mRNA SARS-CoV-2 vaccine","volume":"30","author":"Dias","year":"2021","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2025082701111514000_14.8.e244878.6","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1056\/NEJMe2106315","article-title":"SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia","volume":"384","author":"Cines","year":"2021","journal-title":"N Engl J Med"},{"key":"2025082701111514000_14.8.e244878.7","unstructured":"AstraZeneca\u2019s COVID-19 vaccine: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets. Available: https:\/\/www.ema.europa.eu\/en\/news\/astrazenecas-covid-19-vaccine-ema-finds-possible-link-very-rare-cases-unusual-blood-clots-low-blood [Accessed Apr 2021]."},{"key":"2025082701111514000_14.8.e244878.8","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00956-2021"},{"key":"2025082701111514000_14.8.e244878.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n954"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-244878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:11:22Z","timestamp":1756282282000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-244878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":9,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,16]]},"published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1136\/bcr-2021-244878"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-244878","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}