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This report presents a case of a life-threatening HLH occurring 6\u2009weeks after a pauci-symptomatic COVID-19 infection in a previously healthy adult. A bone marrow aspirate confirmed the HLH and the patient was successfully treated with dexamethasone and etoposide. To our knowledge, this is the first case of HLH occurring as a postacute COVID-19 syndrome following a pauci-symptomatic initial infection.<\/jats:p>","DOI":"10.1136\/bcr-2021-245031","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T11:36:33Z","timestamp":1631532993000},"page":"e245031","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome"],"prefix":"10.1136","volume":"14","author":[{"given":"Daniel","family":"Wiseman","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, McGill University Health Centre, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lin","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9897-7589","authenticated-orcid":false,"given":"Jean-Pierre","family":"Routy","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre, Montreal, Qu\u00e9bec, Canada"},{"name":"Division of Haematology, McGill University Health Centre, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordan","family":"Samoukovic","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, McGill University Health Centre, Montreal, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"2025082801454734000_14.9.e245031.1","unstructured":"World Health Organization . 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