{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T14:39:50Z","timestamp":1782052790509,"version":"3.54.5"},"reference-count":16,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,10,2]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Porphyria cutanea tarda is the most common type of porphyria. It is associated with a deficiency of uroporphyrinogen decarboxylase enzyme responsible for heme synthesis. Clinical manifestations are predominantly dermatological and very rarely present with ocular involvement. Although scleral thinning in the interpalpebral area is a well-documented entity, sight-threatening corneal involvement is rarely described. We, herein report a case of a 58-year-old man who presented with ocular surface dryness, photophobia and mild redness. Slit-lamp biomicroscopy revealed corneo-scleral thinning in both eyes. The diagnosis was confirmed with a urine porphyrin test, serum iron and serum ferritin levels. We started him on conservative management after which he was lost to follow-up. He presented again after 6\u2009years with total corneal opacification and progressive loss of vision in the right eye.<\/jats:p>","DOI":"10.1136\/bcr-2021-245160","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T13:28:37Z","timestamp":1634650117000},"page":"e245160","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Sight-threatening progressive corneo-scleral involvement in porphyria cutanea tarda"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-6981","authenticated-orcid":false,"given":"Sonali","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Ophthalomology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhata","family":"Vidhata","sequence":"additional","affiliation":[{"name":"Sadguru Netra Chikitsalaya, Chitrakoot, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash","family":"Prasad","sequence":"additional","affiliation":[{"name":"Divyadrishti Eye Centre, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"2025082701472103000_14.10.e245160.1","unstructured":"Nuttall KL . 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