{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:58Z","timestamp":1756339558046,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,3,29]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Zieve syndrome is a rare condition which occurs in patients with severe alcohol abuse. It is typically characterised by the triad of jaundice, haemolytic anaemia and transient hyperlipidaemia. In the following report, we present the case of a man in his 30s who was admitted to our emergency department with severe epigastric pain and signs of alcohol intoxication. Blood samples showed signs of severe hyperlipidaemia and jaundice. Due to massive hyperlipidaemia, laboratory measurements of triglycerides were impaired and the blood samples had a \u2018yellowish\u2019 and \u2018creamy\u2019 texture. In order to prevent pancreatitis, plasmapheresis was performed. Subsequently, triglyceride concentration dropped and the patient was discharged a few days later in significantly improved physical condition. In the following case report, we discuss plasmapheresis as a possible treatment for patients with severe Zieve syndrome in addition to conventional symptomatic therapy.<\/jats:p>","DOI":"10.1136\/bcr-2021-245257","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T03:58:24Z","timestamp":1666583904000},"page":"e245257","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Zieve syndrome presenting with lipaemia and treated by plasmapheresis"],"prefix":"10.1136","volume":"15","author":[{"given":"Lauren Eleonore","family":"Sams","sequence":"first","affiliation":[{"name":"Division of Cardiology, Medizinische Klinik und Poliklinik I, LMU Klinikum, Munchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Krappe","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Medizinische Klinik und Poliklinik IV, LMU Klinikum, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Czihal","sequence":"additional","affiliation":[{"name":"Division of Angiology, Medizinische Klinik und Poliklinik IV, LMU Klinikum, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Michael","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Medizinische Klinik und Poliklinik IV, LMU Klinikum, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"2025082710151967000_15.4.e245257.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-48-3-471"},{"key":"2025082710151967000_15.4.e245257.2","doi-asserted-by":"crossref","DOI":"10.14309\/crj.0000000000000133","article-title":"Zieve's syndrome presenting with severe hypertriglyceridemia","volume":"6","author":"Choudhry","year":"2019","journal-title":"ACG Case Rep J"},{"key":"2025082710151967000_15.4.e245257.3","first-page":"2058","article-title":"Zwischenbilanz des Sieve-Syndroms","volume":"95","author":"Heck KK","year":"1970","journal-title":"Dtsch Med Wochenschr"},{"key":"2025082710151967000_15.4.e245257.4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/ijlh.1990.12.2.159","article-title":"Alcohol-associated haemolysis in Zieve's syndrome: a clinical and laboratory study of five cases","volume":"12","author":"Melrose","year":"1990","journal-title":"Clin Lab Haematol"},{"key":"2025082710151967000_15.4.e245257.5","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jacl.2018.03.086","article-title":"Clinical features and outcomes of severe, very severe, and extreme hypertriglyceridemia in a regional health service","volume":"12","author":"Zafrir","year":"2018","journal-title":"J Clin Lipidol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-245257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:15:31Z","timestamp":1756314931000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-245257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":5,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,6]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bcr-2021-245257"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-245257","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}