{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:10:06Z","timestamp":1756368606393,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,2,10]]},"published-print":{"date-parts":[[2022,3]]},"abstract":"\n Acalypha indica<\/jats:italic> is a tropical herb found in Asia. The entire plant, especially the leaves, is used in herbal medicine for several therapeutic purposes. Acute intravascular haemolysis and methaemoglobinaemia have been reported in patients who consume this herb. We present a case of a previously healthy middle-aged man who ingested boiled leaves of A. indica<\/jats:italic>. The patient developed clinical symptoms and signs of intravascular haemolysis 7\u2009days after ingestion. Peripheral blood smear showed typical findings of glucose-6-phosphate dehydrogenase (G6PD) deficiency with acute haemolysis. The G6PD activity was low during active haemolysis. The G6PD level, however, returned to normal after 4\u2009months of follow-<\/jats:italic>up. The patient was further tested for common G6PD gene mutations in Southeast Asia and was negative. Ingestion of A. indica<\/jats:italic> may induce transient G6PD deficiency, which in this patient led to acute haemolysis and methaemoglobinaemia.<\/jats:p>","DOI":"10.1136\/bcr-2021-245447","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T12:31:09Z","timestamp":1646137869000},"page":"e245447","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Acalypha indica<\/i>\n -<\/b>induced transient glucose-6-phosphate dehydrogenase deficiency with acute haemolysis"],"prefix":"10.1136","volume":"15","author":[{"given":"Sapol","family":"Thepwiwatjit","sequence":"first","affiliation":[{"name":"Internal Medicine, Khon Kaen University Faculty of Medicine, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nattiya","family":"Teawtrakul","sequence":"additional","affiliation":[{"name":"Internal Medicine, Khon Kaen University Faculty of Medicine, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanachit","family":"Krikeerati","sequence":"additional","affiliation":[{"name":"Internal Medicine, Khon Kaen University Faculty of Medicine, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thapanawong","family":"Mitsungnern","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"2025082800525969000_15.3.e245447.1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jep.2017.06.019","article-title":"A review of Acalypha indica L. (Euphorbiaceae) as traditional medicinal plant and its therapeutic potential","volume":"207","author":"Zahidin","year":"2017","journal-title":"J Ethnopharmacol"},{"key":"2025082800525969000_15.3.e245447.2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2147\/IJGM.S263199","article-title":"Clinical Characteristics of Acalypha indica Poisoning","volume":"13","author":"Pradoo","year":"2020","journal-title":"Int J Gen Med"},{"key":"2025082800525969000_15.3.e245447.3","doi-asserted-by":"crossref","DOI":"10.1186\/s13104-018-3286-9","article-title":"A vegetable-induced hemolytic crisis in a G6PD deficient person: a case report","volume":"11","author":"Ehelepola","year":"2018","journal-title":"BMC Res Notes"},{"key":"2025082800525969000_15.3.e245447.4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s13312-021-2113-x","article-title":"Acalypha indica-Induced hemolysis and methemoglobinemia in a child with G6PD deficiency","volume":"58","author":"Pallapothu","year":"2021","journal-title":"Indian Pediatr"},{"key":"2025082800525969000_15.3.e245447.5","first-page":"46","article-title":"Acalypha indica induced haemolysis in G6PD deficiency","volume":"39","author":"Lamabadusuriya","year":"1994","journal-title":"Ceylon Med J"},{"key":"2025082800525969000_15.3.e245447.6","doi-asserted-by":"publisher","DOI":"10.1177\/004947559602600113"},{"key":"2025082800525969000_15.3.e245447.7","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-223369","article-title":"Severe acute haemolytic anaemia associated with severe methaemoglobinaemia in a G6PD-deficient man","volume":"83","author":"Rehman","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025082800525969000_15.3.e245447.8","doi-asserted-by":"crossref","DOI":"10.4084\/MJHID.2021.029","article-title":"Prevalence and molecular characterization of glucose-6-phosphate dehydrogenase (G6PD) deficiency in females from previously malaria endemic regions in northeastern Thailand and identification of a novel G6PD variant","volume":"13","author":"Dechyotin","year":"2021","journal-title":"Mediterr J Hematol Infect Dis"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-245447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:53:07Z","timestamp":1756367587000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-245447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3,1]]},"published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1136\/bcr-2021-245447"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-245447","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}