{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:42:15Z","timestamp":1793284935036,"version":"4.5.0"},"reference-count":15,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,1,6]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Anaplastic large cell lymphoma (ALCL) is a subtype of T cell non-Hodgkin\u2019s lymphoma and can present as an extranodal disease. Primary ALCL of skeletal muscle is rare. We report a case of ALK-positive ALCL involving the left thigh and anterior chest wall in a 12-year-old male child. The fine needle aspiration cytology from the lesion showed cellular smears with singly scattered and occasional clusters of large pleomorphic atypical cells. A diagnosis of poorly differentiated malignant neoplasm was rendered. On core biopsy, the histomorphological features posed a diagnostic challenge with a myriad of morphological mimickers. The diagnosis was established by excluding specific entities by relevant immunostains and confirming the diagnosis by strong expression of CD30 and ALK on immunohistochemistry. Fluorescence in-situ hybridisation confirmed the characteristic t(2:5) translocation. Presentation of ALCL with skeletal muscle involvement is uncommon, and the diagnosis relies on broadening the diagnostic possibilities and judicious use of immunohistochemical markers.<\/jats:p>","DOI":"10.1136\/bcr-2021-245685","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T11:34:19Z","timestamp":1644233659000},"page":"e245685","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["ALK-positive anaplastic large cell lymphoma of skeletal muscle masquerading as soft tissue sarcoma"],"prefix":"10.1136","volume":"15","author":[{"given":"Deepika","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-2603","authenticated-orcid":false,"given":"Vikarn","family":"Vishwajeet","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Ramzan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-389X","authenticated-orcid":false,"given":"Poonam Abhay","family":"Elhence","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine, All India Institute of Medical Sciences, Jodhpur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"2025082708284514000_15.2.e245685.1","unstructured":"Falini B , Lamant-Rochaix L , Campo E , et al . Anaplastic large cell lymphoma, ALK-positive. In: Swerdlow SH , Campo E , Harris NL , et al , eds. World Health organization classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press, 2017: 413\u20135."},{"key":"2025082708284514000_15.2.e245685.2","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1182\/blood.V96.12.3681","article-title":"CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features","volume":"96","author":"Stein","year":"2000","journal-title":"Blood"},{"key":"2025082708284514000_15.2.e245685.3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000335744","article-title":"Primary anaplastic large cell lymphoma of the psoas muscle: a case report and literature review","volume":"127","author":"Kounami","year":"2012","journal-title":"Acta Haematol"},{"key":"2025082708284514000_15.2.e245685.4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5114\/pjp.2021.106448","article-title":"Primary anaplastic large T-cell lymphoma of the psoas muscle","volume":"72","author":"Pecorella","year":"2021","journal-title":"Pol J Pathol"},{"key":"2025082708284514000_15.2.e245685.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-005-1063-z"},{"key":"2025082708284514000_15.2.e245685.6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0165-4608(00)00285-5","article-title":"Primary CD30\/Ki-1 positive anaplastic large cell lymphoma of skeletal muscle with der(17)t(1;17)(q11;p11)","volume":"122","author":"Ishii","year":"2000","journal-title":"Cancer Genet Cytogenet"},{"key":"2025082708284514000_15.2.e245685.7","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198705000-00004"},{"key":"2025082708284514000_15.2.e245685.8","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.3892\/ol.2015.3087","article-title":"Anaplastic large cell lymphoma with primary involvement of the skeletal muscle: a case report","volume":"9","author":"Yang","year":"2015","journal-title":"Oncol Lett"},{"key":"2025082708284514000_15.2.e245685.9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200109000-00005"},{"key":"2025082708284514000_15.2.e245685.10","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.31"},{"key":"2025082708284514000_15.2.e245685.11","unstructured":"Weiss LM , Jaffe R , Facchetti F . Tumours derived from Langerhans cells. In: Swerdlow SH , Campo E , Harris NL , et al , eds. World Health organization classification of tumours of haematopoietic and lymphoid tissues. 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