{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:09:56Z","timestamp":1777770596222,"version":"3.51.4"},"reference-count":16,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,11,23]]},"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We report the case of a 73-year-old woman who intentionally ingested 400 mg of amlodipine in a suicidal attempt who initially presented with hypotension which persisted despite aggressive therapy with fluid resuscitation, multiple pressor support, high-dose insulin therapy and calcium infusion. Her haemodynamic instability evolved to include bradycardia requiring atropine and transcutaneous pacing. Eventually she required salvage therapy with intravenous lipid emulsion (ILE) therapy . Despite all aggressive therapy, she developed multi-organ failure resulting in death. The literature on high-dose insulin euglycaemic therapy (HIET) and ILE therapy shows mixed results with some showing significant improvement in haemodynamic status. In our case, it had no significant positive impact on the outcome.<\/jats:p>","DOI":"10.1136\/bcr-2021-245711","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T10:46:56Z","timestamp":1642416416000},"page":"e245711","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Multi-organ dysfunction as a presentation of calcium channel blocker intoxication"],"prefix":"10.1136","volume":"15","author":[{"given":"Abdul-Fatawu","family":"Osman","sequence":"first","affiliation":[{"name":"Michigan State University, East Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-5594","authenticated-orcid":false,"given":"Rohan Madhu","family":"Prasad","sequence":"additional","affiliation":[{"name":"Michigan State University, East Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Marein","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical care, Sparrow Health System, Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical care, Sparrow Health System, Lansing, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"2025082710541416000_15.1.e245711.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911043411907"},{"key":"2025082710541416000_15.1.e245711.2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/bcp.12763","article-title":"Calcium channel antagonist and beta-blocker overdose: antidotes and adjunct therapies","volume":"81","author":"Graudins","year":"2016","journal-title":"Br J Clin 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