{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:57:08Z","timestamp":1787320628764,"version":"build-2736575974"},"reference-count":3,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,12,23]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Lambert-Eaton Myasthenic Syndrome (LEMS) is a neuromuscular junction defect that results in weakness. It is rarely seen in children and most commonly is associated with small-cell lung cancer. Diagnosis of LEMS requires characteristic electromyogram (EMG) findings and the detection of antibodies directed against voltage-gated calcium channels. We report the case of an 8-year-old female child who presented with profound weakness found to have EMG evidence of a neuromuscular junction defect and detectable antivoltage-gated calcium channel antibodies. She received plasma exchange electrophoresis, intravenous immunoglobulin, oral steroids and amifampridine with some clinical improvement. We present a case of a child with a demonstrated autoimmune propensity and no evidence of malignancy, thereby adding to the 12 previously reported cases of LEMS in children.<\/jats:p>","DOI":"10.1136\/bcr-2021-245773","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T10:50:30Z","timestamp":1646045430000},"page":"e245773","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Lambert-Eaton myasthenic syndrome in a young girl"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1192-2572","authenticated-orcid":false,"given":"Sarah E","family":"Moor","sequence":"first","affiliation":[{"name":"Yale School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tova","family":"Gardin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale-New Haven Hospital, New Haven, Connecticut, USA"},{"name":"Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"2025082709292856000_15.2.e245773.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00431-8"},{"key":"2025082709292856000_15.2.e245773.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-0528-7"},{"key":"2025082709292856000_15.2.e245773.3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.pediatrneurol.2013.08.009","article-title":"Lambert-Eaton syndrome, an unrecognized treatable pediatric neuromuscular disorder: three patients and literature review","volume":"50","author":"Hajjar","year":"2014","journal-title":"Pediatr Neurol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-245773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:29:32Z","timestamp":1756312172000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-245773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":3,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,28]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/bcr-2021-245773"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-245773","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}