{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:18:46Z","timestamp":1789640326247,"version":"4.0.0"},"reference-count":4,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,10,7]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Rituximab (RTX) is a monoclonal anti-CD20 antibody used to treat non-Hodgkin's lymphoma. RTX-organising pneumonia (RTX-OP) is a rare complication following treatment with RTX. We report a 49\u2010year\u2010old woman, with CD5-negative B-cell lymphoproliferative disorder who developed high-grade fever, dyspnoea and dry cough 3\u2009days after the first dose of RTX. She responded poorly to antibiotics and antifungal therapy. High-resolution CT (HRCT) of the chest revealed bilateral patchy ground-glass opacities with arcade-like signs suggestive of OP. She was pulsed with intravenous methylprednisolone and RTX was discontinued. She was able to be weaned off the non-invasive ventilation (NIV) support and was discharged with maintenance prednisolone 1\u2009mg\/kg and tapered over 6 weeks. A repeated HRCT of the chest at 6 weeks showed a total resolution of OP. This highlights the early occurrence at day 3 of RTX-OP following the first dose of RTX and the complete resolution with steroid therapy.<\/jats:p>","DOI":"10.1136\/bcr-2021-245837","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T12:31:11Z","timestamp":1635424271000},"page":"e245837","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Single dose of rituximab causing organising pneumonia in a patient with B-cell lymphoproliferative disorder"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-4789","authenticated-orcid":false,"given":"Andrea Yu-Lin","family":"Ban","sequence":"first","affiliation":[{"name":"Respiratory Unit, Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0750-3087","authenticated-orcid":false,"given":"Boon Hau","family":"Ng","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7526-361X","authenticated-orcid":false,"given":"Mohamed","family":"Faisal","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathika","family":"Rajah","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"2025082700122004000_14.10.e245837.1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker290"},{"key":"2025082700122004000_14.10.e245837.2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080209"},{"key":"2025082700122004000_14.10.e245837.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/160421","article-title":"Rituximab induced interstitial lung disease in patients with non-hodgkin\u2019s lymphoma: a clinical study of six cases and review of the literature","volume":"2014","author":"Krishnaswamy","year":"2014","journal-title":"Lymphoma"},{"key":"2025082700122004000_14.10.e245837.4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000327681","article-title":"Rituximab-induced interstitial lung disease: case report and literature review","volume":"87","author":"Zayen","year":"2011","journal-title":"Pharmacology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-245837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:12:27Z","timestamp":1756278747000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-245837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":4,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10,28]]},"published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1136\/bcr-2021-245837"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-245837","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}