{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T04:20:09Z","timestamp":1770524409997,"version":"3.49.0"},"reference-count":6,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,9,27]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Lymphoepithelial carcinoma (LEC) of the larynx is an extremely rare tumour which, unlike its nasopharyngeal counterpart, has shown a propensity to affect elderly Caucasian men and is not commonly associated with Epstein-Barr virus. We present a 70-year-old Chinese man who complained of hoarseness and dysphagia. Nasoendoscopy revealed a left supraglottic tumour. Preoperative MRI (in particular Diffusion Weighted Imaging) showed the possibility of two distinct components within a tumour. The patient underwent total pharyngolaryngectomy and bilateral selective neck dissection. The final histology report confirmed the presence of a tumour with two distinct components: predominant LEC with a smaller conventional (keratinising) squamous cell carcinoma component. The patient recovered well after surgery and subsequently underwent adjuvant radiotherapy. Final staging was pT3 N2c M0 (AJCC stage IVA). Follow-up over 2 years revealed no tumour recurrence.<\/jats:p>","DOI":"10.1136\/bcr-2021-245945","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T13:21:24Z","timestamp":1634736084000},"page":"e245945","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Lymphoepithelial carcinoma of the larynx: an extremely rare tumour in a patient of Chinese descent"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-4053","authenticated-orcid":false,"given":"Jiawei Alexander","family":"Yap","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-1565","authenticated-orcid":false,"given":"Manish M","family":"Bundele","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming Yann","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian Park Nam","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"2025082803302460000_14.10.e245945.1","unstructured":"Gaulard P , Bishop J , Gillison M . Lymphoepithelial carcinoma. In: El-Naggar AK , Chan JKC , Grandis JR , et al , eds. Who classification of head and neck tumours, 4th. Lyon, France: International Agency for Research in Cancer, 2017: 90."},{"key":"2025082803302460000_14.10.e245945.2","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12092431","article-title":"Lymphoepithelial carcinoma of larynx and hypopharynx: a rare clinicopathological entity","volume":"12","author":"Faisal","year":"2020","journal-title":"Cancers"},{"key":"2025082803302460000_14.10.e245945.3","article-title":"Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis","volume":"132","author":"Petruzzi","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2025082803302460000_14.10.e245945.4","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0046-8177(96)90311-1","article-title":"Lymphoepithelial carcinoma of the larynx and hypopharynx: study of eight cases with relationship to epstein-barr virus and p53 gene alterations, and review of the literature","volume":"27","author":"MacMillan","year":"1996","journal-title":"Hum Pathol"},{"key":"2025082803302460000_14.10.e245945.5","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1097\/PAS.0000000000001752","article-title":"Mucoacinar carcinoma","volume":"45","author":"Bundele","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"2025082803302460000_14.10.e245945.6","unstructured":"College of American Pathologists (CAP) . Protocol for the examination of specimens from patients with cancers of the larynx, version: 4.1.0.0, note C, 2021. Documents.cap.org. Available: https:\/\/documents.cap.org\/protocols\/cp-headandneck-larynx-17protocol-4001.pdf"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-245945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:30:33Z","timestamp":1756377033000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-245945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":6,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10,20]]},"published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1136\/bcr-2021-245945"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-245945","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}