{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:26:50Z","timestamp":1782311210325,"version":"3.54.5"},"reference-count":10,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,11,14]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Acute retinal necrosis (ARN) is a rare ocular emergency caused mainly by viral entities. ARN may be caused by Herpes zoster virus (HZV) and Herpes simplex virus (HSV), both HSV-1 and HSV-2. ARN mostly present in 20\u201360 years old immunocompetent adults. A 7-year-old girl presented to the eye clinic with complaints of left eye redness noted by her mother for 2\u20133\u2009days. On examination with indirect ophthalmoscopy, no hypopyon was seen in either eye. In the left eye fundus view was hazy. Ultrasound B-scan performed showed exudative retinal detachment. PCR of ocular fluid was positive for HSV-1 DNA. The patient was started on topical steroids and antibiotics and systemic antivirals. In addition, she also received intravitreal ganciclovir 4\u2009mg\/0.1\u2009mL three times under general anaesthesia. At her last follow-up, 3 years from her presentation, her right eye examination was within normal limits, and left eye showed thick vitreous bands with a posterior vitreous detachment, and left inferotemporal retinal scarring.<\/jats:p>","DOI":"10.1136\/bcr-2021-245984","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T11:50:12Z","timestamp":1639569012000},"page":"e245984","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Acute retinal necrosis with exudative retinal detachment in a child"],"prefix":"10.1136","volume":"14","author":[{"given":"Benish Aslam","family":"Perhiar","sequence":"first","affiliation":[{"name":"Section of Ophthalmology, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-3189","authenticated-orcid":false,"given":"MA Rehman","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnaz","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Child Health, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"2025082802375365000_14.12.e245984.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70075-3"},{"key":"2025082802375365000_14.12.e245984.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00316-5"},{"key":"2025082802375365000_14.12.e245984.3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/00006454-200201000-00021","article-title":"Acute retinal necrosis syndrome in a child","volume":"21","author":"Chen","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"2025082802375365000_14.12.e245984.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2012.02.005"},{"key":"2025082802375365000_14.12.e245984.5","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0002-9394(14)70390-3","article-title":"Twenty years' delay of fellow eye involvement in herpes simplex virus type 2-associated bilateral acute retinal necrosis syndrome","volume":"122","author":"Schlingemann","year":"1996","journal-title":"Am J Ophthalmol"},{"key":"2025082802375365000_14.12.e245984.6","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200108000-00008"},{"key":"2025082802375365000_14.12.e245984.7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/INF.0b013e318186258f","article-title":"Acute retinal necrosis in primary herpes simplex virus type I infection","volume":"28","author":"Mora","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"2025082802375365000_14.12.e245984.8","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/INF.0000000000000137","article-title":"Neonatal herpes simplex virus type-1 central nervous system disease with acute retinal necrosis","volume":"33","author":"Fong","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"2025082802375365000_14.12.e245984.9","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0161-6420(90)32356-4","article-title":"Rapidly progressive acute retinal necrosis secondary to herpes simplex virus, type 1","volume":"97","author":"Duker","year":"1990","journal-title":"Ophthalmology"},{"key":"2025082802375365000_14.12.e245984.10","first-page":"1","article-title":"Multimodal imaging of a severe case of neonatal acute retinal necrosis and lens vacuoles associated with herpes simplex virus infection","volume":"6","author":"Kinoshita","year":"2021","journal-title":"Ocul Immunol Inflamm"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-245984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:38:04Z","timestamp":1756373884000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-245984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12,15]]},"published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1136\/bcr-2021-245984"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-245984","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]}}}