{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T16:58:03Z","timestamp":1781974683282,"version":"3.54.5"},"reference-count":16,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,11,18]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Myasthenia gravis (MG) is an autoimmune condition affecting the neuromuscular junction characterised by weakness and fatiguability, carrying a high morbidity if treatment is delayed. A clear association with thymoma has led to management with thymectomy as a common practice, but MG presenting post-thymectomy has rarely been reported. We present a case of an 82-\u2009year-old woman developing fatigue, ptosis and dysarthria 3 months after thymectomy. After a clinical diagnosis of MG was made, she responded well to prompt treatment with prednisolone and pyridostigmine. Her anti-acetylcholine receptor antibody (anti-AChR) subsequently came back positive. Our systematic review reveals that post-thymectomy MG can be categorised as early-onset or late-onset form with differing aetiology, and demonstrated correlation between preoperative anti-AChR titres and post-thymectomy MG. The postulated mechanisms for post-thymectomy MG centre around long-lasting peripheral autoantibodies. Clinicians should actively look for MG symptoms in thymoma patients and measure anti-AChR preoperatively to aid prognostication.<\/jats:p>","DOI":"10.1136\/bcr-2021-246005","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T11:02:02Z","timestamp":1638442922000},"page":"e246005","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Post-thymectomy myasthenia gravis: a case report and systematic review of literature"],"prefix":"10.1136","volume":"14","author":[{"given":"Louise","family":"Gurowich","sequence":"first","affiliation":[{"name":"General Surgery, Taunton and Somerset NHS Foundation Trust, Taunton, UK"},{"name":"Neurology, Swindon and Marlborough NHS Trust, Swindon, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Neurology, Swindon and Marlborough NHS Trust, Swindon, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rice","sequence":"additional","affiliation":[{"name":"Histopathology, Royal Brompton Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Yiin","sequence":"additional","affiliation":[{"name":"Neurology, Swindon and Marlborough NHS Trust, Swindon, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"2025082712462024000_14.12.e246005.1","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1056\/NEJMra1602678","article-title":"Myasthenia gravis","volume":"375","author":"Gilhus","year":"2016","journal-title":"N Engl J Med Overseas 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