{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:25:31Z","timestamp":1762543531743,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,10,8]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Sarcoidosis is a systemic, idiopathic and granulomatous disease, which most commonly affects the skin, lungs and lymph nodes but can affect virtually any organ. Neurosarcoidosis can be the presenting or the only clinical manifestation accounting for 5%\u201315% of sarcoid diagnoses. In contrast to uveitis which is the most common ophthalmic manifestation, neuro-ophthalmic signs are uncommon in sarcoidosis. Optic neuropathy is the most common neuro-ophthalmic sign (70% in one series). Sarcoid-related optic neuropathy commonly presents with a picture similar to optic neuritis. Less commonly, optic nerve involvement occurs secondary to compressive lesions, or from direct granulomatous infiltration. Neuroimaging is crucial to identify the location of the lesion. We describe a case of sarcoid-related compressive optic neuropathy and third nerve palsy and highlight the challenging nature of neurosarcoidosis in a patient without a prior diagnosis of the disease.<\/jats:p>","DOI":"10.1136\/bcr-2021-246024","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T07:16:38Z","timestamp":1636614998000},"page":"e246024","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Rare presentation of sarcoidosis with optic neuropathy and third nerve palsy"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-4923","authenticated-orcid":false,"given":"Mohamed","family":"Seifelnasr","sequence":"first","affiliation":[{"name":"Ophthalmology, King's College Hospital NHS Foundation Trust, London, UK"},{"name":"Ophthalmology, Alexandria University, Alexandria, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-9808","authenticated-orcid":false,"given":"Magnus","family":"Theodorsson","sequence":"additional","affiliation":[{"name":"Ophthalmology, King's College Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Hart","sequence":"additional","affiliation":[{"name":"Radiology, King's College Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eoin","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Ophthalmology, King's College Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"2025082623222083000_14.11.e246024.1","doi-asserted-by":"publisher","DOI":"10.1080\/08820530802007382"},{"key":"2025082623222083000_14.11.e246024.2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000270"},{"key":"2025082623222083000_14.11.e246024.3","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp042"},{"key":"2025082623222083000_14.11.e246024.4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/01658107.2018.1467935","article-title":"Abdominal sarcoidosis presenting as bilateral simultaneous optic disc granulomas","volume":"43","author":"Elnahry","year":"2019","journal-title":"Neuroophthalmology"},{"key":"2025082623222083000_14.11.e246024.5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1474-4422(04)00805-1","article-title":"Neurosarcoidosis: a clinical dilemma","volume":"3","author":"Hoitsma","year":"2004","journal-title":"The Lancet Neurology"},{"key":"2025082623222083000_14.11.e246024.6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.151977"},{"key":"2025082623222083000_14.11.e246024.7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/qjmed\/92.2.103","article-title":"Central nervous system sarcoidosis-diagnosis and management","volume":"92","author":"Zajicek","year":"1999","journal-title":"QJM \u2013 Mon J Assoc Physicians"},{"key":"2025082623222083000_14.11.e246024.8","first-page":"169","article-title":"Isolated third nerve palsy due to sarcoidosis","volume":"14","author":"Ueyama","year":"1997","journal-title":"Sarcoidosis Vasc Diffus Lung Dis"},{"key":"2025082623222083000_14.11.e246024.9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/01658107.2014.928826","article-title":"Isolated pupil-involving third nerve palsy as the first presentation of sarcoidosis","volume":"38","author":"Bansal","year":"2014","journal-title":"Neuro-Ophthalmology"},{"key":"2025082623222083000_14.11.e246024.10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00408-015-9826-3","article-title":"Diagnostic utility of angiotensin-converting enzyme in sarcoidosis: a population-based study","volume":"194","author":"Ungprasert","year":"2016","journal-title":"Lung"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-246024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:22:30Z","timestamp":1756275750000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-246024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":10,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,11]]},"published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1136\/bcr-2021-246024"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-246024","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2021,11]]}}}