{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:40:25Z","timestamp":1756280425736,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","issue":"8","funder":[{"name":"Aneurin Bevan Health Board","award":["Fellowship Code SF0158134"],"award-info":[{"award-number":["Fellowship Code SF0158134"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,6,26]]},"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>The purpose of this report is to present the outcomes of Descemet\u2019s stripping endothelial keratoplasty (DSEK), followed by deep anterior lamellar keratoplasty (DALK), as an alternative to penetrating keratoplasty (PKP) for different indications. Patients in this retrospective case series underwent manual DSEK, followed by manual DALK, for tectonic and\/or visual reasons. It includes three cases that underwent DSEK followed by DALK as an alternative to PKP for the following conditions: failed PKP and stromal scarring, aphakic bullous keratopathy and herpetic stromal scarring, and herpetic corneal perforation. All cases had successful anatomical repair with visual improvement. Many corneal conditions involving endothelium and stroma have been traditionally managed with PKP. However, in certain settings with high risk of complications, this might not be an appropriate option. Therefore, for these cases, we propose management with DSEK followed by DALK as an alternative approach in a \u2018closed anterior chamber\u2019 fashion, which can reduce the risk of significant, sometimes irreversible, complications.<\/jats:p>","DOI":"10.1136\/bcr-2021-246124","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T11:15:58Z","timestamp":1660907758000},"page":"e246124","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Case series of staged lamellar corneal grafting with thin manual Descemet\u2019s stripping endothelial keratoplasty, followed by manual deep anterior lamellar keratoplasty, as an alternative to penetrating keratoplasty"],"prefix":"10.1136","volume":"15","author":[{"given":"Abdo Karim","family":"Tourkmani","sequence":"first","affiliation":[{"name":"Royal Gwent Hospital, Newport, Wales, 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