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The steroid was stopped after 6\u2009weeks and sirolimus was continued with serum drug level monitoring and serial imaging of the malformation. After 4\u2009months of sirolimus, the AVM remained at the same size as at the start of treatment, thus we propose that the drug may have arrested the growth of the lesion. This case highlights the use of sirolimus in management of AVMs in infants.<\/jats:p>","DOI":"10.1136\/bcr-2021-246265","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T11:37:10Z","timestamp":1646739430000},"page":"e246265","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Sirolimus used for treatment of retroperitoneal arteriovenous malformation in a premature neonate"],"prefix":"10.1136","volume":"15","author":[{"given":"Chinmay","family":"Chetan","sequence":"first","affiliation":[{"name":"Neonatology, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suprabha","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Neonatology, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Suryawanshi","sequence":"additional","affiliation":[{"name":"Neonatology, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema","family":"Garegrat","sequence":"additional","affiliation":[{"name":"Neonatology, Bharati Vidyapeeth Deemed University Medical College, Pune, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"2025082800360645000_15.3.e246265.1","unstructured":"ISSVA classification for vascular anomalies. 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