{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:03:45Z","timestamp":1756425825773,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,12,14]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>We report the case of a 54-year-old immunocompetent woman who presented with a primary T-cell\/histiocyte-rich large B-cell lymphoma (TCHRLBCL) of the central nervous system without systemic involvement, diagnosed by means of a brain biopsy. She was treated with corticosteroids and we subsequently started chemotherapy with rituximab, methotrexate, ifosfamide and intrathecal cytarabine. The patient\u2019s symptoms gradually improved over the first weeks and we followed-up with autologous haematopoietic cell transplantation. The patient has been in complete remission for a year. Primary TCHRLBCL of the central nervous system in an immunocompetent patient is an extremely rare condition that requires a multidisciplinary approach. This case highlights the importance of undergoing a sequential work-up and establishing a treatment despite the absence of evidence-based guidelines.<\/jats:p>","DOI":"10.1136\/bcr-2021-246355","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T11:54:45Z","timestamp":1644321285000},"page":"e246355","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Unusual primary central nervous system T-cell\/histiocyte-rich large B-cell lymphoma: a case report"],"prefix":"10.1136","volume":"15","author":[{"given":"Jaime","family":"Toro","sequence":"first","affiliation":[{"name":"Department Neurology, Hospital Universitario\u2212Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, Colombia"},{"name":"Universidad de Los Andes, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Department Neurology, Hospital Universitario\u2212Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Fl\u00f3rez","sequence":"additional","affiliation":[{"name":"Department Neurology, Hospital Universitario\u2212Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Sebastian","family":"Rivera","sequence":"additional","affiliation":[{"name":"Neurology, Fundacion Santa Fe de Bogota, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"2025082802160911000_15.2.e246355.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-321349"},{"key":"2025082802160911000_15.2.e246355.2","unstructured":"World Health Organization . WHO classification of tumours of haematopoietic and lymphoid tissues. 4th edn. Lyon: WHO Classification of Tumours, 2017."},{"key":"2025082802160911000_15.2.e246355.3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4081\/rt.2015.6084","article-title":"T-cell\/histiocyte-rich large B-cell lymphoma presenting as a primary central nervous system lymphoma","volume":"7","author":"Advani","year":"2015","journal-title":"Rare Tumors"},{"key":"2025082802160911000_15.2.e246355.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"},{"key":"2025082802160911000_15.2.e246355.5","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now207"},{"key":"2025082802160911000_15.2.e246355.6","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-4-384"},{"key":"2025082802160911000_15.2.e246355.7","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1200\/JCO.2017.72.7602","article-title":"Primary CNS lymphoma","volume":"35","author":"Grommes","year":"2017","journal-title":"J Clin Oncol"},{"key":"2025082802160911000_15.2.e246355.8","doi-asserted-by":"crossref","first-page":"175628641879356","DOI":"10.1177\/1756286418793562","article-title":"Primary central nervous system lymphoma","volume":"11","author":"L\u00f6w","year":"2018","journal-title":"Ther Adv Neurol Disord"},{"key":"2025082802160911000_15.2.e246355.9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.13.524"},{"key":"2025082802160911000_15.2.e246355.10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/01.pai.0000132199.47017.35","article-title":"T-Cell\/Histiocyte-Rich large B-cell lymphoma displays a heterogeneity similar to diffuse large B-cell lymphoma","volume":"13","author":"Wang","year":"2005","journal-title":"Applied Immunohistochemistry & Molecular Morphology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-246355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:16:21Z","timestamp":1756372581000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-246355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,8]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/bcr-2021-246355"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-246355","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}