{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:10:05Z","timestamp":1756321805069,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,1,27]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>We present a case of a previously asymptomatic 63-year-old woman who presented with worsening dyspnoea for 3 weeks. Initial transthoracic and later transoesophageal echocardiography confirmed biventricular non-compaction cardiomyopathy and a large secundum atrial septal defect (ASD) measuring 1.4\u2009cm. Additionally, there was a haemodynamically significant left to right shunt causing acute decompensated systolic heart failure. She eventually underwent closure of the septal defect using a AMPLATZER Septal Occluder device. Decision to close the defect was made as the left to right shunt was causing severe pulmonary hypertension and acute heart failure. Since most heart failure treatments involve lowering of the LV afterload there was consideration that this could cause right to left shunting and could cause an Eisenmenger physiology. Hence the AMPLATZER Septal Occluder device was placed to eliminate the shunt through the ASD. The ASD combined with the non-compaction posed significant treatment challenge in this case.<\/jats:p>","DOI":"10.1136\/bcr-2021-246385","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T10:50:59Z","timestamp":1646045459000},"page":"e246385","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Acute-onset heart failure secondary to biventricular non-compaction cardiomyopathy and atrial septal defect in a woman presenting in the seventh decade"],"prefix":"10.1136","volume":"15","author":[{"given":"Purva","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Oncology, East Tennessee State University, Johnson City, Tennessee, USA"},{"name":"Department of Internal Medicine, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yash","family":"Jobanputra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, Florida, USA"},{"name":"Department of Cardiovascular Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Chait","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqas","family":"Ghumman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Miami Miller School of Medicine Palm Beach Regional Campus, Atlantis, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"2025082711430681000_15.2.e246385.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.2.507"},{"key":"2025082711430681000_15.2.e246385.2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3282fdc939"},{"key":"2025082711430681000_15.2.e246385.3","first-page":"77","article-title":"Biventricular non-compaction cardiomyopathy","volume":"63","author":"Gupta","year":"2015","journal-title":"J Assoc Physicians India"},{"key":"2025082711430681000_15.2.e246385.4","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/CIRCULATIONAHA.106.174287","article-title":"Contemporary definitions and classification of the cardiomyopathies: an American heart association scientific statement from the Council on clinical cardiology, heart failure and transplantation Committee; quality of care and outcomes research and Functio","volume":"113","author":"Maron","year":"2006","journal-title":"Circulation [Internet]"},{"key":"2025082711430681000_15.2.e246385.5","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951101000646"},{"key":"2025082711430681000_15.2.e246385.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61282-4"},{"key":"2025082711430681000_15.2.e246385.7","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00392-019-01465-3","article-title":"Clinical and genetic insights into non-compaction: a meta-analysis and systematic review on 7598 individuals","volume":"108","author":"Kayvanpour","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"2025082711430681000_15.2.e246385.8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/AC.70.6.3120173","article-title":"Non-compaction cardiomyopathy: a genetically and clinically heterogeneous disorder","volume":"70","author":"Rooms","year":"2015","journal-title":"Acta Cardiol"},{"key":"2025082711430681000_15.2.e246385.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.01.070"},{"key":"2025082711430681000_15.2.e246385.10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.15420\/ucs.2017:9:2","article-title":"The impact of an atrial septal defect on hemodynamics in patients with heart failure","volume":"11","author":"Shah","year":"2017","journal-title":"US Cardiology Review"},{"key":"2025082711430681000_15.2.e246385.11","first-page":"e4032","article-title":"Acute ST-segment elevation myocardial infarction as the first manifestation of essential thrombocytosis","volume":"11","author":"Sharma","year":"2019","journal-title":"Cureus"},{"key":"2025082711430681000_15.2.e246385.12","unstructured":"Celik S , G\u00f6rg\u00fcl\u00fc S , G\u00fcrol T . [Myocardial noncompaction: two cases and review]. Anadolu Kardiyol Derg 2003;3."},{"key":"2025082711430681000_15.2.e246385.13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/jcecho.jcecho_50_17","article-title":"Biventricular noncompaction cardiomyopathy accompanied by severe pulmonary valvular stenosis and patent foramen ovale","volume":"28","author":"Karauzum","year":"2018","journal-title":"J Cardiovasc Echogr"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-246385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:43:15Z","timestamp":1756320195000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-246385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,28]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/bcr-2021-246385"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-246385","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}