{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:40:04Z","timestamp":1756320004796,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,11,26]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p>A man aged above 70 years old with a medical history of ulcerative colitis presented with unintentional weight loss. A pancreatic mass associated with pancreatic duct dilatation was detected on imaging procedures. Initial investigations including fine needle aspiration and cytology examination were inconclusive. A diagnosis of intraductal tubulopapillary neoplasm (ITPN) was made with histopathology and immunohistochemistry examination on a surgically resected specimen. Two years after surgery, the patient remained well with no radiological evidence of recurrence.<\/jats:p>\n               <jats:p>ITPN is a rare pancreatic duct tumour with limited case reports in medical literature. Risk factors are not well established. We report the first case of ITPN occurring in a patient with ulcerative colitis. A typical presentation of this rare tumour is reported to encourage clinicians to consider ITPN in the differential diagnoses of a pancreatic mass.<\/jats:p>","DOI":"10.1136\/bcr-2021-246398","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T10:00:58Z","timestamp":1671703258000},"page":"e246398","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Intraductal tubulopapillary neoplasm"],"prefix":"10.1136","volume":"15","author":[{"given":"Catherine","family":"Yu","sequence":"first","affiliation":[{"name":"General Medicine, Austin Health, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Lokan","sequence":"additional","affiliation":[{"name":"Pathology, Austin Health, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Jackett","sequence":"additional","affiliation":[{"name":"Pathology, Austin Health, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Nikfarjam","sequence":"additional","affiliation":[{"name":"Hepatobiliary\/Transplant Unit, Department of Surgery, Austin Hospital, Melbourne, Vicotira, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Mills","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences, Monash University, Churchill, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"2025082711042346000_15.12.e246398.1","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/modpathol.2017.60","article-title":"Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma","volume":"30","author":"Basturk","year":"2017","journal-title":"Mod Pathol"},{"key":"2025082711042346000_15.12.e246398.2","unstructured":"Bosman FT FC , Hruban RH , Theise ND . Who classification of tumours of the digestive system. 5th ed. IARC Press: Lyon, 2019."},{"key":"2025082711042346000_15.12.e246398.3","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a162e5"},{"key":"2025082711042346000_15.12.e246398.4","first-page":"87","article-title":"Intraductal neoplasms of the pancreas: an update","volume":"33","author":"A\u015fkan","year":"2017","journal-title":"Turk Patoloji Derg"},{"key":"2025082711042346000_15.12.e246398.5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00423-016-1391-6","article-title":"Clinicopathological features and surgical outcomes of intraductal tubulopapillary neoplasm of the pancreas: a systematic review","volume":"401","author":"Date","year":"2016","journal-title":"Langenbecks Arch Surg"},{"key":"2025082711042346000_15.12.e246398.6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/PAS.0000000000000782","article-title":"Intraductal Tubulopapillary neoplasm of the pancreas: a clinicopathologic and immunohistochemical analysis of 33 cases","volume":"41","author":"Basturk","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"2025082711042346000_15.12.e246398.7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.9738\/INTSURG-D-14-00172.1","article-title":"A resected case of intraductal tubulopapillary neoplasm of the pancreas: report of a case","volume":"100","author":"Kitaguchi","year":"2015","journal-title":"Int Surg"},{"key":"2025082711042346000_15.12.e246398.8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/apt.15785","article-title":"Inflammatory bowel disease and pancreatic cancer: a Scandinavian register-based cohort study 1969-2017","volume":"52","author":"Everhov","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"2025082711042346000_15.12.e246398.9","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317993"},{"key":"2025082711042346000_15.12.e246398.10","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/modpathol.2015.61","article-title":"Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases","volume":"28","author":"Schlitter","year":"2015","journal-title":"Mod Pathol"},{"key":"2025082711042346000_15.12.e246398.11","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/RCT.0b013e31826d1fc8","article-title":"Imaging studies of intraductal tubulopapillary neoplasms of the pancreas: 2-tone duct sign and cork-of-wine-bottle sign as indicators of intraductal tumor growth","volume":"36","author":"Motosugi","year":"2012","journal-title":"J Comput Assist Tomogr"},{"key":"2025082711042346000_15.12.e246398.12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5152\/dir.2019.18215","article-title":"Multimodality imaging studies of intraductal tubulopapillary neoplasms of the pancreas","volume":"25","author":"Kim","year":"2019","journal-title":"Diagn Interv Radiol"},{"key":"2025082711042346000_15.12.e246398.13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000448386","article-title":"Intraductal Tubulopapillary neoplasm of the pancreas masquerading as pancreatic neuroendocrine carcinoma: review of the literature with a case report","volume":"60","author":"Savant","year":"2016","journal-title":"Acta Cytol"},{"key":"2025082711042346000_15.12.e246398.14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.surg.2013.12.032","article-title":"When to perform a pancreatoduodenectomy in the absence of positive histology? a consensus statement by the International Study group of pancreatic surgery","volume":"155","author":"Asbun","year":"2014","journal-title":"Surgery"},{"key":"2025082711042346000_15.12.e246398.15","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1097\/RLU.0b013e318292f12f","article-title":"18F-Fdg uptake in intraductal tubulopapillary neoplasm of the pancreas","volume":"39","author":"Someya","year":"2014","journal-title":"Clin Nucl Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-246398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:04:30Z","timestamp":1756317870000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-246398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":15,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,22]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/bcr-2021-246398"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-246398","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}