{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:47:36Z","timestamp":1773092856117,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,9,28]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Subacute thyroiditis following vaccination is an uncommon presentation of thyrotoxicosis. As the world undertakes its largest immunisation campaign to date in an attempt to protect the population from COVID-19 infections, an increasing number of rare post vaccine side effects are being observed. We report a case of a middle-aged woman who presented with painful thyroid swelling following the second dose of the COVID-19 mRNA vaccine BNT162b2 (Pfizer\u2013BioNTech) with clinical, biochemical and imaging features consistent with destructive thyrotoxicosis. Symptomatic management only was required for the self-limiting episode. Thyroiditis typically has a mild and self-limiting course and thus this observation should not deter people from vaccination, as COVID-19 infection has a far greater morbidity and mortality risk than thyroiditis.<\/jats:p>","DOI":"10.1136\/bcr-2021-246425","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T11:27:28Z","timestamp":1636457248000},"page":"e246425","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["COVID-19 vaccine-associated subacute thyroiditis: an unusual suspect for de Quervain\u2019s thyroiditis"],"prefix":"10.1136","volume":"14","author":[{"given":"Mohammad Sadiq","family":"Jeeyavudeen","sequence":"first","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan W","family":"Patrick","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fraser W","family":"Gibb","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK"},{"name":"Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna R","family":"Dover","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK"},{"name":"Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"2025082701443376000_14.11.e246425.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31965-4"},{"key":"2025082701443376000_14.11.e246425.2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-5"},{"key":"2025082701443376000_14.11.e246425.3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.4103\/ijem.IJEM_237_18","article-title":"Occurrence of subacute thyroiditis following influenza vaccination","volume":"22","author":"Passah","year":"2018","journal-title":"Indian J Endocrinol Metab"},{"key":"2025082701443376000_14.11.e246425.4","article-title":"Autoimmune\/Inflammatory syndrome induced by adjuvants and thyroid autoimmunity","volume":"7","author":"Watad","year":"2016","journal-title":"Front Endocrinol"},{"key":"2025082701443376000_14.11.e246425.5","first-page":"620","article-title":"Granulomatous thyroiditis: a case report and literature review","volume":"47","author":"Trivedi","year":"2017","journal-title":"Ann Clin Lab Sci"},{"key":"2025082701443376000_14.11.e246425.6","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaa144","article-title":"SARS-CoV-2 (COVID-19) and the endocrine system","volume":"4","author":"Lundholm","year":"2020","journal-title":"J Endocr Soc"},{"key":"2025082701443376000_14.11.e246425.7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.617089","article-title":"Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases","volume":"11","author":"Vojdani","year":"2020","journal-title":"Front 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      Ratio as a Useful Indicator for Differentiating Destruction Induced Thyrotoxicosis from Graves' Disease","volume":"11","author":"Baral","year":"2017","journal-title":"J Clin Diagn Res"}],"container-title":["BMJ Case 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