{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:02:36Z","timestamp":1756339356980,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,12,21]]},"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Primary splenic diffuse large B-cell lymphoma (PS-DLBCL) is a relatively rare malignancy, and there are no optimal approaches for diagnosis and management. There are less invasive splenic biopsies that effectively obviate diagnostic and elective splenectomies. We report a man in his 50s with 2-day history of pain in the abdomen and who was found to have a splenic mass on PET-CT. A CT-guided core needle splenic biopsy confirmed the diagnosis of PS-DLBCL. He was managed with six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) alone, without splenectomy. The patient attained complete remission, and he is disease free at 6 years of follow-up.<\/jats:p>","DOI":"10.1136\/bcr-2021-246610","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:46:52Z","timestamp":1641296812000},"page":"e246610","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical benefit of R-CHOP without splenectomy in stage I primary splenic diffuse large B-cell lymphoma"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-4025","authenticated-orcid":false,"given":"Tara","family":"Rajendran","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Mangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3351-9517","authenticated-orcid":false,"given":"Jyoti Ramanath","family":"Kini","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Mangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysha","family":"Abna","sequence":"additional","affiliation":[{"name":"Department of Radio-diagnosis and Imaging, Father Muller Medical College, Mangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Prasad","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of General Medicine, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Mangalore, Karnataka, India"},{"name":"Department of Medical Oncology, Mangalore Institute of Oncology, Mangalore, Karnataka, 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