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A multi-disciplinary team comprising neonatologists, paediatric dermatologists, plastic surgeons and medical laboratory scientists at the skin bank, employed a more aggressive surgical approach with the aim of avoiding potentially catastrophic morbidity, including sagittal sinus haemorrhage and brain herniation. Out of several surgical options, the team used a staged artificial dermal matrix (Integra) and cultured epithelial autograft application, followed by regular wound dressing, and eventually allowed the child to achieve complete epithelialisation of her trunk, and most of scalp before she was discharged from hospital.<\/jats:p>","DOI":"10.1136\/bcr-2021-246627","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T22:14:46Z","timestamp":1644876886000},"page":"e246627","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Challenges in the management of extensive aplasia cutis congenita"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-4402","authenticated-orcid":false,"given":"Alvin","family":"Ngeow","sequence":"first","affiliation":[{"name":"Department of Neonatal and Developmental Medicine, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Hui","sequence":"additional","affiliation":[{"name":"Plastic, Reconstructive and Aesthetic Surgery, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin Wen Choong","family":"Chua","sequence":"additional","affiliation":[{"name":"Skin Bank Unit, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-4105","authenticated-orcid":false,"given":"Mark","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Siang","family":"Ong","sequence":"additional","affiliation":[{"name":"Plastic, Reconstructive and Aesthetic Surgery, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woei Bing","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"2025082702373734000_15.2.e246627.1","first-page":"556","article-title":"Extrait d\u2019une lettre au sujet de trios enfants de la meme mere nes avec partie des extremites denuee de peau","volume":"26","author":"Cordon","year":"1767","journal-title":"J Med Chir Pharm"},{"key":"2025082702373734000_15.2.e246627.2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12106"},{"key":"2025082702373734000_15.2.e246627.3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/jp.2017.142","article-title":"A practical approach to the evaluation and treatment of an infant with aplasia cutis congenita","volume":"38","author":"Humphrey","year":"2018","journal-title":"J Perinatol"},{"key":"2025082702373734000_15.2.e246627.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70082-0"},{"key":"2025082702373734000_15.2.e246627.5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1399-0004.1995.tb03968.x","article-title":"Aplasia cutis congenita and associated disorders: an update","volume":"47","author":"Evers","year":"1995","journal-title":"Clin Genet"},{"key":"2025082702373734000_15.2.e246627.6","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000638"},{"key":"2025082702373734000_15.2.e246627.7","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/ced.14331","article-title":"Classification of aplasia cutis congenita: a 25-year review of cases presenting to a tertiary paediatric dermatology department","volume":"45","author":"Sathishkumar","year":"2020","journal-title":"Clin Exp Dermatol"},{"key":"2025082702373734000_15.2.e246627.8","unstructured":"GLASSON DW , DUNCAN GM . 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