{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:51:18Z","timestamp":1789419078962,"version":"build-2803163510"},"reference-count":5,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,1,13]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Burkitt lymphoma is a highly aggressive B cell non-Hodgkin\u2019s lymphoma characterised by translocation of <jats:italic>MYC<\/jats:italic> gene on chromosome 8. This translocation is usually detected by fluorescent in-situ hybridisation (FISH) studies as part of routine diagnostic work-up and prognostication. FISH testing is commonly done with the break-apart probe (BAP). This case illustrates how this testing can be falsely negative. This patient is a young male diagnosed with Stage I low-risk Burkitt with FISH negative for <jats:italic>MYC<\/jats:italic> translocation initially on BAP testing. Additional testing with dual FISH probe detected <jats:italic>MYC\/IGH<\/jats:italic> translocation. FISH testing using BAPs alone may be falsely negative for <jats:italic>MYC<\/jats:italic> translocations creating a diagnostic challenge and compromising the treatment approach and assessment of prognosis.<\/jats:p>","DOI":"10.1136\/bcr-2021-246687","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T12:03:02Z","timestamp":1644321782000},"page":"e246687","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Burkitt lymphoma: interpreting FISH testing for <i>MYC<\/i> gene rearrangements"],"prefix":"10.1136","volume":"15","author":[{"given":"Purva","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, East Tennessee State University, Johnson City, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Singal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, East Tennessee State University, Johnson City, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Costello","sequence":"additional","affiliation":[{"name":"Department of Watauga Pathology, East Tennessee State University, Johnson City, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koyamangalath","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, East Tennessee State University, Johnson City, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"2025082711345876000_15.2.e246687.1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12178"},{"key":"2025082711345876000_15.2.e246687.2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404340"},{"key":"2025082711345876000_15.2.e246687.3","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.207290"},{"key":"2025082711345876000_15.2.e246687.4","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a004077"},{"key":"2025082711345876000_15.2.e246687.5","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.208140"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-246687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:35:02Z","timestamp":1756319702000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-246687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,8]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/bcr-2021-246687"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-246687","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}