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She subsequently underwent two renal biopsies. The second biopsy showed features consistent with acute tubulointerstitial nephritis. She was commenced on oral steroids, which led to marked improvement of her renal function.<\/jats:p>\n               <jats:p>There are reasons why AKI can occur post vaccination such as prerenal AKI from reduced oral intake postvaccination due to feeling unwell or developing vomiting or diarrhoea. Intravenous fluids were given to this patient but with no meaningful improvement in renal function. She developed a possible reaction to the AstraZeneca COVID-19 vaccine, which led to AKI as supported by the interstitial inflammation and presence of eosinophils on renal biopsy.<\/jats:p>","DOI":"10.1136\/bcr-2021-246841","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T11:50:29Z","timestamp":1652961029000},"page":"e246841","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Acute interstitial nephritis after COVID-19 vaccination"],"prefix":"10.1136","volume":"15","author":[{"given":"Felicia SC","family":"Tan","sequence":"first","affiliation":[{"name":"Renal Medicine, Hull University Teaching Hospitals NHS Trust, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad E","family":"Kabir","sequence":"additional","affiliation":[{"name":"Renal Medicine, Hull University Teaching Hospitals NHS Trust, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Renal Medicine, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"2025082709001535000_15.5.e246841.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.03.010"},{"key":"2025082709001535000_15.5.e246841.2","unstructured":"Dutta SS . 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