{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:28:04Z","timestamp":1759332484375,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,12,26]]},"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>A 41-year-old female presented with dysgeusia, dry eyes, nyctalopia with progressive visual field constriction (due to autoimmune retinopathy) and gastrointestinal symptoms (due to ulcerative colitis). She was subsequently admitted to intensive care with a myasthenic crisis, and CT of the thorax demonstrated a thymoma.<\/jats:p>\n               <jats:p>Following thymectomy and adjuvant radiotherapy, she has remained in complete remission from her ulcerative colitis and myasthenia gravis, her retinopathy has stabilised and there has been no thymoma recurrence over a 10-year postoperative period. There was a brief relapse of her dysgeusia (causing weight loss) and dry eye symptoms 3 years after her surgery, which resolved 8 months later. While the association of thymomas with paraneoplastic syndromes (PNS) is well established, it is unusual to present with multiple PNS, and some of these have only been documented in sparse case reports to date. Thymectomy played a crucial role in improvement and stabilisation of her PNS.<\/jats:p>","DOI":"10.1136\/bcr-2021-246861","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T11:22:19Z","timestamp":1642072939000},"page":"e246861","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["An unusual presentation of thymoma: dysgeusia, ulcerative colitis, keratoconjunctivitis sicca, autoimmune retinopathy and myasthenia gravis"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-4573","authenticated-orcid":false,"given":"Priyanka","family":"Sanghi","sequence":"first","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London, UK"},{"name":"Department of Neuro-Ophthalmology, National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fion","family":"Bremner","sequence":"additional","affiliation":[{"name":"Department of Neuro-Ophthalmology, National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"2025082702413324000_15.1.e246861.1","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1097\/JTO.0000000000000300","article-title":"Paraneoplastic disorders in thymoma patients","volume":"9","author":"Evoli","year":"2014","journal-title":"Journal of Thoracic Oncology"},{"key":"2025082702413324000_15.1.e246861.2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jtcvs.2019.11.052","article-title":"A systematic review of paraneoplastic syndromes associated with thymoma: treatment modalities, recurrence, and outcomes in resected cases","volume":"160","author":"Zhao","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025082702413324000_15.1.e246861.3","doi-asserted-by":"crossref","first-page":"7571","DOI":"10.21037\/jtd-2019-thym-10","article-title":"Autoimmune disorders and paraneoplastic syndromes in thymoma","volume":"12","author":"Blum","year":"2020","journal-title":"J Thorac Dis"},{"key":"2025082702413324000_15.1.e246861.4","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-007-0185-8"},{"key":"2025082702413324000_15.1.e246861.5","article-title":"Myasthenia gravis and its comorbidities","volume":"6","author":"Diaz","year":"2015","journal-title":"J. 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