{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:49:18Z","timestamp":1768531758250,"version":"3.49.0"},"reference-count":21,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,2,8]]},"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Acquired haemophilia A (AHA) is a rare bleeding disorder with high morbidity and mortality, but it is eminently treatable if diagnosis and treatment are prompt. We report a case of AHA in Southeast Asia following the administration of the Pfizer-BioNTech COVID-19 vaccine. A man in his 80s developed multiple bruises 2\u2009weeks after his first dose of the COVID-19 vaccine. Diagnosis was delayed due to his cognitive impairment and low clinical suspicion. This led to a representation with worsening ecchymosis, a left thigh haematoma and symptomatic anaemia. Laboratory testing was notable for an isolated prolongation of the activated partial thromboplastin time, which remained uncorrected in the mixing test. Further testing confirmed the presence of factor VIII (FVIII) inhibitors and low FVIII titres of 6.7%. He responded to treatment with intravenous methylprednisolone and recombinant activated FVII. Screening for autoimmune diseases and malignancies was negative.<\/jats:p>","DOI":"10.1136\/bcr-2021-246922","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T11:15:31Z","timestamp":1646824531000},"page":"e246922","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Case of acquired haemophilia a in Southeast Asia following COVID-19 vaccine"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-7888","authenticated-orcid":false,"given":"Lee","family":"Ai Vuen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Kuala Lipis, Kuala Lipis, Pahang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Aun Su-Yin","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Tengku Ampuan Afzan, Kuantan, Pahang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahlam","family":"Naila Kori","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hospital Tengku Ampuan Afzan, Kuantan, Pahang, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TM","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Hospital Selayang, Batu Caves, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"2025082710091768000_15.3.e246922.1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.230771"},{"key":"2025082710091768000_15.3.e246922.2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32832ca388"},{"key":"2025082710091768000_15.3.e246922.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04654.x"},{"key":"2025082710091768000_15.3.e246922.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04162.x"},{"key":"2025082710091768000_15.3.e246922.5","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00228-010-0852-z","article-title":"Acquired factor VIII haemophilia following influenza vaccination","volume":"66","author":"Moulis","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"2025082710091768000_15.3.e246922.6","doi-asserted-by":"crossref","first-page":"no","DOI":"10.1111\/j.1365-2516.2011.02493.x","article-title":"A case of acquired haemophilia following H1N1 vaccination","volume":"17","author":"Pirrotta","year":"2011","journal-title":"Haemophilia"},{"key":"2025082710091768000_15.3.e246922.7","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/jth.15291","article-title":"A case report of acquired hemophilia following COVID-19 vaccine","volume":"19","author":"Radwi","year":"2021","journal-title":"J Thromb Haemost"},{"key":"2025082710091768000_15.3.e246922.8","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1111\/jth.15421","article-title":"The statistical risk of diagnosing coincidental acquired hemophilia A following anti-SARS-CoV-2 vaccination","volume":"19","author":"Cittone","year":"2021","journal-title":"J Thromb Haemost"},{"key":"2025082710091768000_15.3.e246922.9","doi-asserted-by":"crossref","unstructured":"Lemoine C , Giacobbe AG , Bonifacino E . A case of acquired haemophilia A in a 70-year-old post COVID-19 vaccine. 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