{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:18:40Z","timestamp":1758478720550,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"unspecified","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,1,11]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Neurological manifestations are common in SARS-CoV-2 infection, including life-threatening acute muscle weakness, due to neuromuscular disorders such as acute transverse myelitis (TM) and Guillain-Barr\u00e9 syndrome (GBS). These syndromes can rarely coexist and present as an overlap syndrome. Here, we report a patient who developed acute symmetrical proximal lower limb weakness 5\u2009days after diagnosis of COVID-19. GBS was diagnosed due to the presence of motor signs, albumin-cytological dissociation in cerebrospinal fluid examination and axonal damage according to nerve condition tests. However, abnormal areas on MRI of the thoracic spine and lack of improvement with intravenous immunoglobulin supported a diagnosis of TM. Therefore, a possible overlap between GBS and TM was established. To our knowledge, this is the third case report of GBS\/TM overlap syndrome after COVID-19. The patient\u2019s full and rapid recovery with intravenous corticosteroids and plasmapheresis supports our diagnosis.<\/jats:p>","DOI":"10.1136\/bcr-2021-246967","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T11:33:07Z","timestamp":1644406387000},"page":"e246967","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["A possible Guillain-Barr\u00e9 syndrome\/transverse myelitis overlap syndrome after recent COVID-19"],"prefix":"10.1136","volume":"15","author":[{"given":"Riyadh","family":"Alrubaye","sequence":"first","affiliation":[{"name":"Department of Hospital Medicine\/Internal Medicine Residency Program, Northeast Georgia Health System Inc, Gainesville, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayamala","family":"Bondugula","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northeast Georgia Health System Inc, Gainesville, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya","family":"Baleguli","sequence":"additional","affiliation":[{"name":"Department of GME\/Internal Medicine, Northeast Georgia Health System Inc, Gainesville, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary","family":"Chofor","sequence":"additional","affiliation":[{"name":"Department of GME\/Internal Medicine Residency Program, Northeast Georgia Health System Inc, Gainesville, Georgia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"2025082710260319000_15.2.e246967.1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s13760-020-01421-3","article-title":"Facing acute neuromuscular diseases during COVID-19 pandemic: focus on Guillain-Barr\u00e9 syndrome","volume":"120","author":"Galassi","year":"2020","journal-title":"Acta Neurol 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Acute transverse myelitis (ATM) and Guillain-Barre syndrome (GBS) overlap syndrome in a COVID-19 patient: a case report. Annal Int Med Dent Res 2021 https:\/\/pesquisa.bvsalud.org\/global-literature-on-novel-coronavirus-2019-ncov\/resource\/en\/covidwho-1116203"},{"key":"2025082710260319000_15.2.e246967.15","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4340"},{"key":"2025082710260319000_15.2.e246967.16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s00115-018-0571-8","article-title":"[Neurological side effects of checkpoint inhibitors]","volume":"90","author":"Knauss","year":"2019","journal-title":"Nervenarzt"},{"key":"2025082710260319000_15.2.e246967.17","article-title":"Case reports of pembrolizumab-induced acute inflammatory demyelinating polyneuropathy","volume":"10","author":"Manam","year":"2018","journal-title":"Cureus"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-246967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:26:10Z","timestamp":1756315570000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-246967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,9]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/bcr-2021-246967"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-246967","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}