{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:40:04Z","timestamp":1756280404992,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/bmj.com\/coronavirus\/usage"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,11,14]]},"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Neutropenia is a rare haematological complication of COVID-19 infection in immunocompetent patients. There is sparse literature on neutropenia in patients with COVID-19, except a few case reports. We encountered a similar case in an intensive care unit that developed severe neutropenia on day 24 of illness. Neutropenia resolved spontaneously on 4th day of its appearance. The patient was isolated and kept under close observation, antibiotics were upgraded and strict asepsis was maintained. Thus, we observed in a patient with no comorbidities and uncomplicated neutropenia that strict measures to prevent infection may suffice and the undue risk of hematopoietic therapy can be avoided. An expert opinion should always be sought in such cases as the presence of complications may require an aggressive approach.<\/jats:p>","DOI":"10.1136\/bcr-2021-247057","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:15:53Z","timestamp":1638274553000},"page":"e247057","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Self-limiting severe neutropenia in a patient with COVID-19"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8542-873X","authenticated-orcid":false,"given":"Ram","family":"Singh","sequence":"first","affiliation":[{"name":"Onco-Anaesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brajesh Kumar","family":"Ratre","sequence":"additional","affiliation":[{"name":"Onco-Anaesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-4892","authenticated-orcid":false,"given":"Prashant","family":"Sirohiya","sequence":"additional","affiliation":[{"name":"Onco-Anaesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushma","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"Onco-Anaesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"2025082700232997000_14.11.e247057.1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/130604"},{"key":"2025082700232997000_14.11.e247057.2","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-242683","article-title":"Febrile neutropenia due to COVID-19 in an immunocompetent patient","volume":"14","author":"Devi","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2025082700232997000_14.11.e247057.3","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1002\/ccr3.3369","article-title":"Can COVID-19 cause severe neutropenia?","volume":"8","author":"L\u00f3pez-Pereira","year":"2020","journal-title":"Clin Case Rep"},{"key":"2025082700232997000_14.11.e247057.4","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-242596","article-title":"Delayed, transient and self-resolving neutropenia following COVID-19 pneumonia","volume":"14","author":"Mank","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2025082700232997000_14.11.e247057.5","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28866","article-title":"Post-COVID-19 severe neutropenia","volume":"68","author":"Bouslama","year":"2021","journal-title":"Pediatr Blood Cancer"},{"key":"2025082700232997000_14.11.e247057.6","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s00277-020-04128-w","article-title":"COVID-19 presenting as neutropenic fever","volume":"99","author":"Spencer","year":"2020","journal-title":"Ann Hematol"},{"key":"2025082700232997000_14.11.e247057.7","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofab017","article-title":"Pancytopenia and profound neutropenia as a sequela of severe SARS-CoV-2 infection (COVID-19) with concern for bone marrow involvement","volume":"8","author":"Hernandez","year":"2021","journal-title":"Open Forum Infect Dis"},{"key":"2025082700232997000_14.11.e247057.8","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1200\/OP.20.00197","article-title":"Management of febrile neutropenia associated with SARS-CoV-2 infection in a patient with cancer","volume":"16","author":"Figuero-P\u00e9rez","year":"2020","journal-title":"JCO Oncol Pract"},{"key":"2025082700232997000_14.11.e247057.9","article-title":"COVID-19 in a patient with accidental drug-induced neutropenia","volume":"7","author":"Meyre","year":"2020","journal-title":"Eur J Case Rep Intern Med"},{"key":"2025082700232997000_14.11.e247057.10","doi-asserted-by":"crossref","first-page":"204512532094093","DOI":"10.1177\/2045125320940935","article-title":"The effect of COVID-19 on absolute neutrophil counts in patients taking clozapine","volume":"10","author":"Gee","year":"2020","journal-title":"Ther Adv Psychopharmacol"},{"key":"2025082700232997000_14.11.e247057.11","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.06.010"},{"key":"2025082700232997000_14.11.e247057.12","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jgo.2020.06.021","article-title":"Older patients with cancer and febrile neutropenia in the COVID-19 era: a new concern","volume":"11","author":"Tralongo","year":"2020","journal-title":"J Geriatr Oncol"},{"key":"2025082700232997000_14.11.e247057.13","doi-asserted-by":"crossref","unstructured":"Selim S . 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