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Later gastrointestinal symptoms together with oral and anal ulcerations developed. He was treated with oral zinc therapy and had resolution of recurrent oral ulcerations and significant reduction in severity of anal ulcerations. The functional impact of ZRSR2 mutation on spliceosome assembly is yet to be defined, but has been previously reported in CCUS with a clinical phenotype of macrocytic anaemia.<\/jats:p>","DOI":"10.1136\/bcr-2021-247154","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T11:59:43Z","timestamp":1648555183000},"page":"e247154","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Clonal cytopenia of undetermined significance and atypical Beh\u00e7et\u2019s: the importance of zinc"],"prefix":"10.1136","volume":"15","author":[{"given":"Patricia","family":"Leonard","sequence":"first","affiliation":[{"name":"School of Medicine, Curtin University, Bentley, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Louw","sequence":"additional","affiliation":[{"name":"Molecular Haematology, PathWest Laboratory Medical WA, Murdoch, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Prentice","sequence":"additional","affiliation":[{"name":"Neurology, Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9881-0260","authenticated-orcid":false,"given":"Melita","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Haematology, Royal Perth Hospital, Perth, Western Australia, Australia"},{"name":"School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"2025082709565923000_15.3.e247154.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4902941","article-title":"High Incidence of Gastrointestinal Ulceration and Cytogenetic Aberration of Trisomy 8 as Typical Features of Beh\u00e7et\u2019s Disease Associated with Myelodysplastic Syndrome: A Series of 16 Consecutive Chinese Patients from the Shanghai Beh\u00e7et\u2019s Disease Database and Comparison with the Literature","volume":"2018","author":"Shen","year":"2018","journal-title":"Biomed Res Int"},{"key":"2025082709565923000_15.3.e247154.2","doi-asserted-by":"publisher","DOI":"10.1086\/505915"},{"key":"2025082709565923000_15.3.e247154.3","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt239"},{"key":"2025082709565923000_15.3.e247154.4","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502284"},{"key":"2025082709565923000_15.3.e247154.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-631747"},{"key":"2025082709565923000_15.3.e247154.6","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.69"},{"key":"2025082709565923000_15.3.e247154.7","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease. 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