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We discuss possible mechanisms that might explain this unusual case and advocate for tissue confirmation in select cases, where there is diagnostic doubt or when the disease pattern does not clearly follow the recognised natural history. Therefore, if regression occurs\u2014whether spontaneous or in response to treatment\u2014it can be better understood and subsequent therapies recommended.<\/jats:p>","DOI":"10.1136\/bcr-2021-247212","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T11:33:40Z","timestamp":1644406420000},"page":"e247212","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous regression of metastatic hepatocellular carcinoma following 3 weeks of lenvatinib"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-5716","authenticated-orcid":false,"given":"Lauren","family":"Curry","sequence":"first","affiliation":[{"name":"Department of Medicine, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warda","family":"Limaye","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-4705","authenticated-orcid":false,"given":"Ravi","family":"Ramjeesingh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada"},{"name":"Division of Medical Oncology, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"2025082711511331000_15.2.e247212.1","unstructured":"International Agency for Research on Cancer WHO . 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