{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:10:27Z","timestamp":1756368627457,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,4,1]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>A woman in her late teens with a history of Juvenile idiopathic arthritis (JIA) and ongoing sicca symptoms presented with syncope. Upon admission, she was found to be bradycardic with a second-degree atrioventricular (AV) block. After infectious, structural and metabolic aetiologies had been ruled out, she was worked up for rheumatologic causes.<\/jats:p>\n               <jats:p>Our patient had elevated titres of anti-Sjogren syndrome (SS) antibodies anti-Ro antibodies and was diagnosed with AV block secondary to SS. She was treated with a permanent pacemaker. Patient was followed up in clinic where she denied further syncopal episodes and was started on secretagogues for sicca symptoms.<\/jats:p>","DOI":"10.1136\/bcr-2021-247337","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T11:48:20Z","timestamp":1649418500000},"page":"e247337","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Sjogren syndrome presenting as atrioventricular block in an adult"],"prefix":"10.1136","volume":"15","author":[{"given":"Moiz","family":"Ehtesham","sequence":"first","affiliation":[{"name":"Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Fortune","sequence":"additional","affiliation":[{"name":"Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Asim","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Peredo-Wende","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Albany Medical Center, Albany, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"2025082800452133000_15.4.e247337.1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/656340"},{"key":"2025082800452133000_15.4.e247337.2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bpobgyn.2019.09.001","article-title":"Autoimmune-mediated congenital heart block","volume":"64","author":"Wainwright","year":"2020","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2025082800452133000_15.4.e247337.3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/art.1780350209","article-title":"Anti-Ro\/SS-A antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome, an experimental model. in vitro electrophysiologic and immunocytochemical studies","volume":"35","author":"Alexander","year":"1992","journal-title":"Arthritis Rheum"},{"key":"2025082800452133000_15.4.e247337.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.10.635"},{"key":"2025082800452133000_15.4.e247337.5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3904\/kjim.2011.26.2.213","article-title":"Complete atrioventricular block in adult Sj\u00f6gren's syndrome with anti-Ro autoantibody","volume":"26","author":"Sung","year":"2011","journal-title":"Korean J Intern Med"},{"key":"2025082800452133000_15.4.e247337.6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.5152\/eurjrheum.2018.18019","article-title":"Anti-Ro antibodies and complete heart block in adults with Sj\u00f6gren's syndrome","volume":"5","author":"Jobling","year":"2018","journal-title":"Eur J Rheumatol"},{"key":"2025082800452133000_15.4.e247337.7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5606\/ArchRheumatol.2018.6492","article-title":"Association of Anti-Ro\/Sj\u00f6gren's syndrome type A antibodies and complete atrioventricular block in an adult with Sj\u00f6gren's syndrome","volume":"33","author":"Tam","year":"2018","journal-title":"Arch Rheumatol"},{"key":"2025082800452133000_15.4.e247337.8","doi-asserted-by":"crossref","DOI":"10.1186\/s13052-017-0373-9","article-title":"The autoimmune burden in juvenile idiopathic arthritis","volume":"43","author":"Tronconi","year":"2017","journal-title":"Ital J Pediatr"},{"key":"2025082800452133000_15.4.e247337.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.10.1190"},{"key":"2025082800452133000_15.4.e247337.10","doi-asserted-by":"publisher","DOI":"10.1148\/rg.315105222"},{"key":"2025082800452133000_15.4.e247337.11","doi-asserted-by":"crossref","DOI":"10.1007\/s11886-020-01430-x","article-title":"The role of autoantibodies in arrhythmogenesis","volume":"23","author":"Li","year":"2020","journal-title":"Curr Cardiol Rep"},{"key":"2025082800452133000_15.4.e247337.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1300484"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-247337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:45:29Z","timestamp":1756367129000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-247337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,8]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bcr-2021-247337"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-247337","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}