{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:25:52Z","timestamp":1790259952574,"version":"4.1.0"},"reference-count":11,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,1,9]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Haemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening disease of disproportionate immune activation. We present a case of a 25-year-old woman who is postnatal day 26 status post lower segment caesarean section who came with fever, breathlessness and abdominal pain in shock in the background of a malarial infection 3\u2009days ago, which was initially evaluated on the lines of fever with multiple organ dysfunction syndrome. On further evaluation turned out to fulfil the criteria for secondary HLH seemingly triggered by an infectious cause or an autoimmune phenomenon. On further assessment, she was found to be positive for antiphospholipid antibodies which forced other possible diagnoses such as catastrophic antiphospholipid antibody syndrome into contention.<\/jats:p>","DOI":"10.1136\/bcr-2021-247376","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T10:26:19Z","timestamp":1643797579000},"page":"e247376","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Rare association of haemophagocytic lymphohistiocytosis (HLH) and antiphospholipid syndrome (APS) in postpartum period: a considerable overlap?"],"prefix":"10.1136","volume":"15","author":[{"given":"Roger","family":"B Rathna","sequence":"first","affiliation":[{"name":"Critical Care Medicine, St John's Medical College Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1794-2569","authenticated-orcid":false,"given":"Arkadeep","family":"Dhali","sequence":"additional","affiliation":[{"name":"General Medicine, St John's Medical College Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athul Kurien","family":"Varghese","sequence":"additional","affiliation":[{"name":"General Medicine, St John's Medical College Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitanya","family":"H Balakrishnan","sequence":"additional","affiliation":[{"name":"General Medicine, St John's Medical College Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"2025082723365930000_15.2.e247376.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-5710(97)00584-7"},{"key":"2025082723365930000_15.2.e247376.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"2025082723365930000_15.2.e247376.3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-5-387"},{"key":"2025082723365930000_15.2.e247376.4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0002-9343(97)89509-5","article-title":"Autoimmune-associated hemophagocytic syndrome","volume":"102","author":"Kumakura","year":"1997","journal-title":"Am J Med"},{"key":"2025082723365930000_15.2.e247376.5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.025759"},{"key":"2025082723365930000_15.2.e247376.6","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu394oa"},{"key":"2025082723365930000_15.2.e247376.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.09.010"},{"key":"2025082723365930000_15.2.e247376.8","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"2025082723365930000_15.2.e247376.9","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2020.153321","article-title":"Can we truly diagnose adult secondary hemophagocytic lymphohistiocytosis (hLH)? A critical review of current paradigms","volume":"218","author":"Naymagon","year":"2021","journal-title":"Pathol Res Pract"},{"key":"2025082723365930000_15.2.e247376.10","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.tjog.2018.10.027","article-title":"Postpartum flare up of systemic lupus erythematosus: pulmonary diffused alveolar hemorrhage","volume":"57","author":"Lu","year":"2018","journal-title":"Taiwan J Obstet Gynecol"},{"key":"2025082723365930000_15.2.e247376.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07124.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-247376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:37:09Z","timestamp":1756363029000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-247376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,2]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/bcr-2021-247376"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-247376","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}