{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:03Z","timestamp":1756339503063,"version":"3.44.0"},"reference-count":53,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,4,17]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>A woman in her 80s reported of generalised pruritus, which was treated with phototherapy and steroid administration. Two months after onset, lymph node biopsy revealed CD4+ angioimmunoblastic\u2009T-cell lymphoma with systemic superficial nodal involvement. Intractable prurigo was judged as T-cell lymphoma related. After effective chemotherapy (7\u2009months later), skin nodules appeared multifocally, including on the lip, thumb and lower leg. The biopsied infiltrative lesion on the right lower leg microscopically revealed subcutaneous growth of atypical plasmablasts with nearly 100% Ki-67 labelling and Epstein-Barr virus (EBV)-encoded small nuclear RNA positivity. Plasmablastic lymphoma (CD45\/CD19\/CD38\/CD138\/MUM1+, CD20\/CD79a\/PAX5-) was suspected. Immunoglobulin light-chain restriction and nuclear expression of c-myc protein were undetectable, and the ulcers were spontaneously epithelialised by the cessation of steroid administration. After 10 months, non-progressive prurigos persisted on the extremities, but without regrowth of nodal T-cell lymphoma and cutaneous lymphoproliferative lesion. Reactive nature of the EBV-induced mucocutaneous plasmablastic growth (EBV-positive mucocutaneous ulcer, plasmablastic type) is discussed.<\/jats:p>","DOI":"10.1136\/bcr-2021-247430","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T12:16:49Z","timestamp":1651839409000},"page":"e247430","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Epstein-Barr virus-positive mucocutaneous ulcer, plasmablastic type, associated with nodal CD4+ angioimmunoblastic T-cell lymphoma and generalised pruritus: a self-limiting lymphoproliferative disorder resembling cutaneous plasmablastic lymphoma"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-9678","authenticated-orcid":false,"given":"Yutaka","family":"Tsutsumi","sequence":"first","affiliation":[{"name":"Division of Diagnostic Pathology, Tsutsumi Byori Shindanka Clinic, Inazawa, Aichi, Japan"},{"name":"Department of Medical Technology, Yokkaichi Nursing and Medical Care University, Yokkaichi, Mie, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shimada General Medical Center, Shimada, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soshi","family":"Yanagita","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shimada General Medical Center, Shimada, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-0391","authenticated-orcid":false,"given":"Mitsuhiro","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Shimada General Medical Center, Shimada, Shizuoka, 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