{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:08:26Z","timestamp":1784333306939,"version":"3.55.0"},"reference-count":12,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,1,7]]},"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Stiff-person syndrome (SPS) is a rare, autoimmune, neurological disorder that often occurs concurrently with other autoimmune disorders, such as type 1 diabetes mellitus, pernicious anaemia, vitiligo and Hashimoto\u2019s thyroiditis. It also can manifest as a paraneoplastic syndrome. Although SPS classically presents with truncal and appendicular stiffness and lumbar hyperlordosis, it can present focally in a single limb (termed <jats:italic>stiff-limb syndrome<\/jats:italic>). Here, we describe a woman with stiff-limb syndrome who initially presented with concerns about right foot swelling and pain. She also was positive for anti-GAD65 (anti-GAD2) antibodies. With treatment, she regained the ability to drive and ambulate without a walker, and she had a noted reduction in stimulus-induced spasms.<\/jats:p>","DOI":"10.1136\/bcr-2021-247482","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T11:36:20Z","timestamp":1644233780000},"page":"e247482","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Unusual presentation of stiff-person syndrome in a patient with type 1 diabetes mellitus"],"prefix":"10.1136","volume":"15","author":[{"given":"Bala","family":"Munipalli","sequence":"first","affiliation":[{"name":"Mayo Clinic Hospital, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaimin S","family":"Shah","sequence":"additional","affiliation":[{"name":"Mayo Clinic Hospital, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"2025082708194531000_15.2.e247482.1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.5.633"},{"key":"2025082708194531000_15.2.e247482.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315688"},{"key":"2025082708194531000_15.2.e247482.3","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-009-0013-9"},{"key":"2025082708194531000_15.2.e247482.4","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199907)42:7<1312::AID-ANR2>3.0.CO;2-W"},{"key":"2025082708194531000_15.2.e247482.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)76151-1"},{"key":"2025082708194531000_15.2.e247482.6","first-page":"421","article-title":"Progressive fluctuating muscular rigidity and spasm (\"stiff-man\" syndrome); report of a case and some observations in 13 other cases","volume":"31","author":"Moersch","year":"1956","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"2025082708194531000_15.2.e247482.7","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1001\/jamaneurol.2013.4442","article-title":"Childhood onset of stiff-man syndrome","volume":"70","author":"Clardy","year":"2013","journal-title":"JAMA Neurol"},{"key":"2025082708194531000_15.2.e247482.8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20529"},{"key":"2025082708194531000_15.2.e247482.9","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.991"},{"key":"2025082708194531000_15.2.e247482.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0876-1"},{"key":"2025082708194531000_15.2.e247482.11","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25565"},{"key":"2025082708194531000_15.2.e247482.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa01167"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-247482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:19:55Z","timestamp":1756307995000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-247482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,7]]},"published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1136\/bcr-2021-247482"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-247482","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}