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Carefully performed osmotic stimulation study, incorporating objective assessment of threshold for thirst and arginine vasopressin (AVP) release is the key to differentiate DP from CDI or psychogenic polydipsia, also termed compulsive water drinking (CWD). Low thirst threshold and high AVP release threshold separate DP from CDI and CWD, respectively. Unlike CWD, desmopressin may be successfully used in DP without concomitant risk of hyponatremia. We describe a child, in whom an initial diagnosis of partial CDI was subsequently revised to DP based on osmotic stimulation test. The child was treated successfully with desmopressin therapy with a target to keep serum osmolality close to thirst threshold.<\/jats:p>","DOI":"10.1136\/bcr-2021-247488","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T10:25:38Z","timestamp":1643797538000},"page":"e247488","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Desmopressin treatment in dipsogenic form of primary polydipsia: keep serum osmolality marginally below thirst threshold for symptomatic relief"],"prefix":"10.1136","volume":"15","author":[{"given":"Neeti","family":"Agrawal","sequence":"first","affiliation":[{"name":"Endocrinology & Metabolism, Medical College and Hospital Kolkata, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3535-4920","authenticated-orcid":false,"given":"Avivar","family":"Awasthi","sequence":"additional","affiliation":[{"name":"Endocrinology & Metabolism, Medical College and Hospital Kolkata, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3316-4525","authenticated-orcid":false,"given":"Partha Pratim","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Endocrinology & Metabolism, Medical College and Hospital Kolkata, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Animesh","family":"Maiti","sequence":"additional","affiliation":[{"name":"Endocrinology & Metabolism, Medical College and Hospital Kolkata, Kolkata, West Bengal, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"2025082702064018000_15.2.e247488.1","doi-asserted-by":"crossref","unstructured":"Robinson AG , Verbalis JG , Pituitary P . 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