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Due to concern for immune reconstitution inflammatory syndrome (IRIS), prednisone was added with significant decrease in the size of the mass. To our knowledge, this is the first reported case of pulmonary cryptococcal-IRIS in an immunocompetent host.<\/jats:p>","DOI":"10.1136\/bcr-2021-247495","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T12:00:08Z","timestamp":1648555208000},"page":"e247495","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory syndrome (IRIS) in an immunocompetent host with pulmonary <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1136","volume":"15","author":[{"given":"Mollie","family":"Tucker","sequence":"first","affiliation":[{"name":"Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Majeed","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Charlotte Hungerford Hospital, Torrington, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-7746","authenticated-orcid":false,"given":"Merceditas S","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"2025082802352453000_15.3.e247495.1","doi-asserted-by":"crossref","unstructured":"Perfect JR . 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