{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:10:17Z","timestamp":1756293017614,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,4,11]]},"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Gallium 68 (<jats:sup>68<\/jats:sup>Ga) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid labelled octreotate ([<jats:sup>68<\/jats:sup>Ga]Ga-DOTA-TATE) positron emission tomography (PET) is an established imaging technique for identifying tumours of neuroendocrine origin and meningiomas; the radiotracer binds to somatostatin receptor type 2 (SSTR2), which is richly expressed by these malignancies. Here, we present a rare case hinting at novel ischaemic stroke detection by [<jats:sup>68<\/jats:sup>Ga]Ga-DOTA-TATE PET scan. The scan was performed 14 days post resection of an atypical meningioma with the intention to assess the extent of residual tumour for radiosurgical treatment of the operative cavity. Surprisingly, the [<jats:sup>68<\/jats:sup>Ga]Ga-DOTA-TATE PET-avid region corresponded to an area of perioperative subacute ischaemic stroke detected by MRI. This case corroborates the two previously reported cases of incidental detection of ischaemic stroke during routine [<jats:sup>68<\/jats:sup>Ga]Ga-DOTA-TATE PET imaging, collectively suggesting the need for caution when interpreting the imaging findings. A possible underlying mechanism for [<jats:sup>68<\/jats:sup>Ga]Ga-DOTA-TATE uptake in stroke is increased SSTR2 expression by macrophages recruited into infarcted tissue.<\/jats:p>","DOI":"10.1136\/bcr-2021-247540","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T11:55:28Z","timestamp":1651233328000},"page":"e247540","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["[<sup>68<\/sup>Ga]Ga-DOTA-TATE uptake in subacute stroke following craniotomy for meningioma: a diagnostic tool for stroke?"],"prefix":"10.1136","volume":"15","author":[{"given":"Justin","family":"Cappuzzo","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, State University of New York, Buffalo, New York, USA"},{"name":"Department of Neuro-Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Popoola","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, State University of New York, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dheerendra","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Lipinski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, State University of New York, Buffalo, New York, USA"},{"name":"Department of Neuro-Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"2025082703401657000_15.4.e247540.1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.352140164"},{"key":"2025082703401657000_15.4.e247540.2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now001"},{"key":"2025082703401657000_15.4.e247540.3","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.19881"},{"key":"2025082703401657000_15.4.e247540.4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13014-021-01875-6","article-title":"68\n               Ga-DOTATATE PET-CT as a tool for radiation planning and evaluating treatment responses in the clinical management of meningiomas","volume":"16","author":"Kowalski","year":"2021","journal-title":"Radiat Oncol"},{"key":"2025082703401657000_15.4.e247540.5","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.149120"},{"key":"2025082703401657000_15.4.e247540.6","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.radcr.2019.09.005","article-title":"Stroke detection with 3 different PET tracers","volume":"14","author":"Dundar","year":"2019","journal-title":"Radiol Case Rep"},{"key":"2025082703401657000_15.4.e247540.7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/RLU.0000000000001894","article-title":"68Ga-DOTATATE uptake in ischemic stroke","volume":"43","author":"Vall\u00e9e","year":"2018","journal-title":"Clin Nucl Med"},{"key":"2025082703401657000_15.4.e247540.8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/bpa.12583","article-title":"Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts","volume":"28","author":"Zrzavy","year":"2018","journal-title":"Brain Pathol"},{"key":"2025082703401657000_15.4.e247540.9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00048.2003"},{"key":"2025082703401657000_15.4.e247540.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.060"},{"key":"2025082703401657000_15.4.e247540.11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/1891569","article-title":"Medical diagnostic tests: a review of test anatomy, phases, and statistical treatment of data","volume":"2019","author":"Bolboac\u0103","year":"2019","journal-title":"Comput Math Methods Med"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-247540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:40:24Z","timestamp":1756291224000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-247540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,29]]},"published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1136\/bcr-2021-247540"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-247540","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}