{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:40Z","timestamp":1787017060883,"version":"build-2736575974"},"reference-count":7,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,5,8]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Intravesical Bacillus Calmette-Gu\u00e9rin (BCG) administration was used to treat bladder carcinoma in a woman in her 60s. Severe bilateral non-granulomatous anterior uveitis and gross papillitis developed subsequently. The severe BCG-induced bilateral uveitis and papillitis were treated with high dose oral corticosteroids, with topical steroids and cycloplegics. Resolution of her ocular symptoms and signs eventuated. On lumbar puncture, no evidence of systemic spread of the BCG was found. Visual acuity returned to 6\/9 in each eye with subsequent resolution of papillitis. Repeat cystoscopy demonstrated no evidence of recurrent bladder tumour.<\/jats:p>\n                  <jats:p>\n                    Hypersensitivity reactions are well recognised with\n                    <jats:italic>Tubercle bacilli<\/jats:italic>\n                    . While both hypersensitivity reactions and dissemination of BCG throughout the body have been previously documented, the literature demonstrates that this case is the first example in which papillitis and bilateral uveitis were the prominent ophthalmological features.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2021-247578","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:57:44Z","timestamp":1653314264000},"page":"e247578","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Papillitis and uveitis complicating Bacillus Calmette-Gu\u00e9rin immunotherapy"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3522-7689","authenticated-orcid":false,"given":"Thomas P","family":"Toohey","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Prince of Wales Hospital and Community Health Services, Randwick, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Wallace","sequence":"additional","affiliation":[{"name":"Dorevitch Pathology, Ballarat Health Services, Ballarat Central, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G","family":"Toohey","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ballarat Base Hospital, Ballarat Central, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"2025082704094283000_15.5.e247578.1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000119"},{"key":"2025082704094283000_15.5.e247578.2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijid.2018.05.006","article-title":"A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer","volume":"72","author":"Bilsen","year":"2018","journal-title":"Int J Infect Dis"},{"key":"2025082704094283000_15.5.e247578.3","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/ar4341","article-title":"Prevalence of HLA-B27 in the New Zealand population: effect of age and ethnicity","volume":"15","author":"Roberts","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"2025082704094283000_15.5.e247578.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.4.268"},{"key":"2025082704094283000_15.5.e247578.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.6.706"},{"key":"2025082704094283000_15.5.e247578.6","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/ceo.12252","article-title":"Ocular involvement following Bacillus Calmette-Guerin immunotherapy for bladder carcinoma","volume":"42","author":"Cugati","year":"2014","journal-title":"Clin Exp Ophthalmol"},{"key":"2025082704094283000_15.5.e247578.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.021"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-247578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:09:48Z","timestamp":1756292988000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-247578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":7,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,23]]},"published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1136\/bcr-2021-247578"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-247578","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}