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Arterial blood gas sampling confirmed hypoxaemia. Given the history and the severe hypoxia, he was managed for pulmonary embolism initially.<\/jats:p>\n               <jats:p>Closer inspection of his arterial blood results showed a methaemoglobin percentage of 20.4%. He was given intravenous methylene blue which resulted in resolution of his symptoms within 30 min. He subsequently confirmed that he was undergoing genetic testing for likely congenital methaemoglobinaemia.<\/jats:p>","DOI":"10.1136\/bcr-2021-247629","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T10:50:57Z","timestamp":1646650257000},"page":"e247629","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Methaemoglobinaemia: a rare cause of chest pain, hypoxia and cyanosis"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0084-744X","authenticated-orcid":false,"given":"Babatunde","family":"Gafaar","sequence":"first","affiliation":[{"name":"North Middlesex University Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ademola","family":"Olaitan","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Hammersmith Hospitals NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharadwaj","family":"Ravi","sequence":"additional","affiliation":[{"name":"North Middlesex University Hospital, London, UK"},{"name":"University Hospitals Sussex NHS Foundation Trust, Worthing, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"2025082712454593000_15.3.e247629.1","first-page":"1","article-title":"Drugs may be induced methemoglobinemia","volume":"5","author":"Alanazi","year":"2017","journal-title":"J Hematol Thrombo Dis"},{"key":"2025082712454593000_15.3.e247629.2","first-page":"e15276","article-title":"Poppers-Induced methemoglobinemia: a curious case of the blues","volume":"13","author":"Tello","year":"2021","journal-title":"Cureus"},{"key":"2025082712454593000_15.3.e247629.3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/bdj.2007.1045","article-title":"Prilocaine induced methaemoglobinaemia in a medically compromised patient. was this an inevitable consequence of the dose administered?","volume":"203","author":"Adams","year":"2007","journal-title":"Br Dent J"},{"key":"2025082712454593000_15.3.e247629.4","unstructured":"Ludlow JT , Wilkerson RG , Nappe TM . 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