{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:40:25Z","timestamp":1756287625459,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,2,24]]},"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>Neonatal Graves\u2019 is uncommon, but a potentially fatal condition caused by transplacental transfer of thyroid stimulating immunoglobulin (TSI). It is seen in 1%\u20135% of infants born to a mother with Graves\u2019 disease. Here, we report a unique case of transient neonatal thyrotoxicosis with positive TSI in a premature neonate born to the mother with primary hypothyroidism. A short course of antithyroid drug treatment leads to significant clinical and biochemical improvement followed by complete recovery.<\/jats:p>","DOI":"10.1136\/bcr-2021-247865","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T11:18:00Z","timestamp":1646824680000},"page":"e247865","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal thyrotoxicosis with maternal hypothyroidism"],"prefix":"10.1136","volume":"15","author":[{"given":"Shruthi","family":"Ravindra","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Manipal Academy of Higher Education (MAHE), Kasturba Medical College Manipal, Udupi, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0851-0411","authenticated-orcid":false,"given":"Sahana","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Manipal Academy of Higher Education (MAHE), Kasturba Medical College Manipal, Udupi, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"2025082702153059000_15.3.e247865.1","doi-asserted-by":"publisher","DOI":"10.1159\/000092454"},{"key":"2025082702153059000_15.3.e247865.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30475-8"},{"key":"2025082702153059000_15.3.e247865.3","first-page":"6","article-title":"Fetal\/neonatal thyrotoxicosis in a newborn from a hypothyroid woman with Hashimoto thyroiditis","volume":"102","author":"Kiefer","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082702153059000_15.3.e247865.4","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1055\/s-0037-1606365","article-title":"Neonatal Graves' disease with maternal hypothyroidism","volume":"7","author":"Akangire","year":"2017","journal-title":"AJP Rep"},{"key":"2025082702153059000_15.3.e247865.5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1515\/jpem-2017-0425","article-title":"Hyperthyroidism in an infant of a mother with autoimmune hypothyroidism with positive TSH receptor antibodies","volume":"31","author":"Joshi","year":"2018","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2025082702153059000_15.3.e247865.6","unstructured":"Gowen CW . Maternal diseases affecting the newborn. Chapter 59. In: Marcdante KJ , Kliegman RM , eds. Nelson essentials of pediatrics. 7th ed. 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