{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:34:14Z","timestamp":1773804854930,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2021,12,19]]},"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>Pituitary gigantism is extremely rare, resulting from excessive secretion of growth hormone (GH) before fusion of epiphysial growth plates. We report a case of a 13-year-old boy, who presented with increased statural growth and headaches since the age of 10 years. On physical examination, his height was 180.7\u2009cm (+3.3\u2009SD) and Tanner stage V. Investigation revealed increased levels of serum age-adjusted and sex-adjusted insulin-like growth factor 1 (IGF-1) and failure of GH suppression during an oral glucose tolerance test (OGTT). MRI of the sellar region revealed a pituitary macroadenoma. He underwent transsphenoidal surgery and histopathological evaluation revealed mammosomatotropic adenoma. Three months after surgery, IGF-1 normalised, nadir GH during OGTT was less than 1\u2009ng\/mL and no residual tumour was found on the MRI. Genetic testing identified a mutation in the <jats:italic>AIP<\/jats:italic> gene. This case emphasises the importance of early diagnosis of gigantism, as treatment delay increases long-term morbidity.<\/jats:p>","DOI":"10.1136\/bcr-2021-247989","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T05:26:30Z","timestamp":1640928390000},"page":"e247989","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Successful treatment of pituitary gigantism"],"prefix":"10.1136","volume":"14","author":[{"given":"Clara","family":"Cunha","sequence":"first","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concei\u00e7\u00e3o","family":"Canas Marques","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Neurocirurgia, Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Sequeira","family":"Duarte","sequence":"additional","affiliation":[{"name":"Endocrinology, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"2025082710000227000_14.12.e247989.1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316282"},{"key":"2025082710000227000_14.12.e247989.2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.6065\/apem.2014.19.2.96","article-title":"Gigantism caused by growth hormone secreting pituitary adenoma","volume":"19","author":"Rhee","year":"2014","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"2025082710000227000_14.12.e247989.3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.12.4379"},{"key":"2025082710000227000_14.12.e247989.4","doi-asserted-by":"crossref","unstructured":"Nadhamuni VS , Iacovazzo D , Evanson J . 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