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An incisional biopsy of the ulcerating lesion confirmed a diagnosis of perforating pilomatrixoma; the lesion was subsequently excised, with no sign of recurrence at 3-month follow-up. The patient had a history of lymphovascular malformation (LVM) and a paternal history of Gardner\u2019s syndrome. Pilomatrixoma and Gardner\u2019s syndrome have a well-documented association in existing literature; aberrant Wnt\/beta-catenin signalling is common to both. Recent laboratory studies suggest this pathway is also implicated in the pathogenesis of LVM.<\/jats:p>","DOI":"10.1136\/bcr-2021-248076","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T11:55:33Z","timestamp":1653479733000},"page":"e248076","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Rare case of multiple and perforating pilomatrixomas in a young girl with lymphovascular malformation reveals a potential new disease association"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2480-7012","authenticated-orcid":false,"given":"Clara","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, NHS Tayside, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, NHS Tayside, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Waterston","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, NHS Tayside, Dundee, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"2025082722572854000_15.5.e248076.1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/pde.13947","article-title":"Syndromes associated with multiple pilomatricomas: when should clinicians be concerned?","volume":"37","author":"Ciriacks","year":"2020","journal-title":"Pediatr Dermatol"},{"key":"2025082722572854000_15.5.e248076.2","unstructured":"C BP L . 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