{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:40:04Z","timestamp":1756374004073,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,12,22]]},"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>We present a case of a woman in her 20s, with a prior history of paediatric sacrococcygeal germ cell tumour, presenting with a 6-month history of perianal pain. An MRI pelvis revealed a heterogeneous soft tissue mass causing destruction of the sacrococcygeal bone. A staging CT demonstrated metastatic deposits in the lungs and hypodense foci in the liver suspicious of metastatic disease. Her alpha-fetoprotein levels were raised and a CT-guided biopsy was in keeping with recurrent germ cell tumour. She was referred to a national centre for the treatment of germ cell tumours in adults and was rechallenged with cisplatin-based multiagent chemotherapy with a curative intent. This case raises the important question of how long we should follow-up these patients and whether they can ever be safely discharged from oncology surveillance.<\/jats:p>","DOI":"10.1136\/bcr-2021-248093","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T11:00:30Z","timestamp":1672830030000},"page":"e248093","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Recurrence of primitive germ cell tumour 20 years on"],"prefix":"10.1136","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-1327","authenticated-orcid":false,"given":"Helen-Cara","family":"Younan","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Keogh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Seckl","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Imperial College Healthcare NHS Trust, London, UK"},{"name":"Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveed","family":"Sarwar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Imperial College Healthcare NHS Trust, London, UK"},{"name":"Faculty of Medicine, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"2025082802274038000_16.1.e248093.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9059382","article-title":"Pediatric germ cell tumors: a developmental perspective","volume":"2018","author":"Pierce","year":"2018","journal-title":"Adv Urol"},{"key":"2025082802274038000_16.1.e248093.2","unstructured":"PDQ Pediatric Treatment Editorial Board . Childhood extracranial germ cell tumors treatment (PDQ\u00ae). Available: https:\/\/www.cancer.gov\/types\/extracranial-germ-cell\/hp\/germ-cell-treatment-pdq# [Accessed 12 Jan 2021]."},{"key":"2025082802274038000_16.1.e248093.3","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008360523160"},{"key":"2025082802274038000_16.1.e248093.4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603014"},{"key":"2025082802274038000_16.1.e248093.5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.21.956"},{"key":"2025082802274038000_16.1.e248093.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603014"},{"key":"2025082802274038000_16.1.e248093.7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1200\/JCO.18.00790","article-title":"Detection of relapse by tumor markers versus imaging in children and adolescents with Nongerminomatous malignant germ cell tumors: a report from the children's Oncology Group","volume":"37","author":"Fonseca","year":"2019","journal-title":"J Clin Oncol"},{"key":"2025082802274038000_16.1.e248093.8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf176"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-248093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:27:49Z","timestamp":1756373269000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-248093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,4]]},"published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1136\/bcr-2021-248093"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-248093","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}