{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:49Z","timestamp":1756339429787,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2022,4,29]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>A woman in her 50s with a background of chronic obstructive pulmonary disease secondary to smoking presented with intermittent chest tightness, dyspnoea and vomiting for 4\u2009days. A presumed diagnosis of acute coronary syndrome (ACS) was made based on dynamic ischaemic ECG changes and elevation in high-sensitivity cardiac troponin T levels. She underwent emergent coronary angiography which demonstrated mild coronary artery disease with left ventriculography suggestive of mid-wall variant Takotsubo cardiomyopathy. Thyroid function tests performed to investigate sinus tachycardia were consistent with hyperthyroidism, and her thyroid-stimulating hormone receptor antibody was elevated. A diagnosis of thyroid storm was made in the setting of a newly diagnosed Graves\u2019 disease and the patient was subsequently commenced on guideline-based therapy. This case demonstrates that Takotsubo cardiomyopathy, a mimic of ACS, is a possible complication of thyroid storm and therefore hyperthyroidism should be considered in the list of differentials in patients presenting with Takotsubo cardiomyopathy.<\/jats:p>","DOI":"10.1136\/bcr-2021-248353","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:17:54Z","timestamp":1653311874000},"page":"e248353","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Takotsubo cardiomyopathy in the setting of thyroid storm"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-4669","authenticated-orcid":false,"given":"Robin WJ","family":"Sia","sequence":"first","affiliation":[{"name":"General Medicine, Northern Hospital Epping, Epping, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Cardiology, Northern Hospital Epping, Epping, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiew","family":"Wong","sequence":"additional","affiliation":[{"name":"Cardiology, Northern Health, Melbourne, Victoria, Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Sharma","sequence":"additional","affiliation":[{"name":"Cardiology, Northern Hospital Epping, Epping, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"2025082703562107000_15.5.e248353.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.072"},{"key":"2025082703562107000_15.5.e248353.2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009003","article-title":"Association of endocrine conditions with takotsubo cardiomyopathy: a comprehensive review","volume":"7","author":"Gupta","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2025082703562107000_15.5.e248353.3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/joim.13189","article-title":"Abnormal thyroid function is common in takotsubo syndrome and depends on two distinct mechanisms: results of a multicentre observational study","volume":"289","author":"Aweimer","year":"2021","journal-title":"J Intern Med"},{"key":"2025082703562107000_15.5.e248353.4","first-page":"97","article-title":"Takotsubo endocrinopathy","volume":"16","author":"Kalra","year":"2020","journal-title":"Eur Endocrinol"},{"key":"2025082703562107000_15.5.e248353.5","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0252"},{"key":"2025082703562107000_15.5.e248353.6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0889-8529(18)30165-8","article-title":"Life-Threatening thyrotoxicosis. thyroid storm","volume":"22","author":"Burch","year":"1993","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2025082703562107000_15.5.e248353.7","unstructured":"Sato H , Tateishi H , Uchida T . Takotsubo-type cardiomyopathy due to multivessel spasm. In: Kodama K , Haze K , Hon M , eds. Clinical aspect of myocardial injury: from ischemia to heart failure. Tokyo, Japan: Kagakuhyouronsha, 1990. : 56\u201364 p.."},{"key":"2025082703562107000_15.5.e248353.8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl032"},{"key":"2025082703562107000_15.5.e248353.9","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/eurheartj\/ehy076","article-title":"International expert consensus document on takotsubo syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology","volume":"39","author":"Ghadri","year":"2018","journal-title":"Eur Heart J"},{"key":"2025082703562107000_15.5.e248353.10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.15420\/ecr.2017:7:2","article-title":"Cardiac magnetic resonance in takotsubo syndrome","volume":"12","author":"Bratis","year":"2017","journal-title":"Eur Cardiol"},{"key":"2025082703562107000_15.5.e248353.11","first-page":"68","article-title":"Late gadolinium enhancement does occur in Tako-tsubo cardiomyopathy - A quantitative cardiac magnetic resonance and speckle tracking strain study","volume":"12","author":"Gaikwad","year":"2016","journal-title":"Int J Cardiol Heart Vasc"},{"key":"2025082703562107000_15.5.e248353.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406761"},{"key":"2025082703562107000_15.5.e248353.13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1152\/ajplegacy.1940.131.2.394","article-title":"Differential sensitization of adrenergic neuro-effector systems by thyroid hormone","volume":"131","author":"Aumann","year":"1940","journal-title":"Am J Physiol"},{"key":"2025082703562107000_15.5.e248353.14","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1670"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2021-248353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:56:30Z","timestamp":1756292190000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2021-248353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,12]]},"published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1136\/bcr-2021-248353"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2021-248353","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}