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The diagnosis relies on indirect measurement of coronary flow reserve (CFR), which may be evaluated both invasively and non-invasively. Assessing CFR not only allows for successful diagnosis of CMD but holds powerful prognostic value for cardiovascular mortality. PET myocardial perfusion imaging is a complementary tool to coronary angiography to achieve diagnosis in a non-invasive, highly accurate and reproducible manner.<\/jats:p>","DOI":"10.1136\/bcr-2021-248354","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T12:03:46Z","timestamp":1648555426000},"page":"e248354","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Coronary microvascular disease: coronary flow reserve and the complementary role of positron emission tomography and angiography"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-5528","authenticated-orcid":false,"given":"Jonathan A","family":"Aun","sequence":"first","affiliation":[{"name":"Medicine, Cardiology Service, Walter Reed National Military Medical Center, Bethesda, Maryland, USA"},{"name":"Uniformed Services University of the Health Sciences, Bethesda, Maryland, 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