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However, despite treatment she rapidly deteriorated and developed severe respiratory failure, requiring mechanical ventilation.<\/jats:p>\n               <jats:p>On further investigation, she tested positive for anti-Jo-1 antibodies and a diagnosis of antisynthetase syndrome sine myositis was made. This led to successful treatment with high dose corticosteroids and intravenous immunoglobulin.<\/jats:p>\n               <jats:p>This case highlights an uncommon presentation of a rare condition, as well as the benefits of working in a multidisciplinary team on the intensive care unit.<\/jats:p>","DOI":"10.1136\/bcr-2021-248358","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T12:03:55Z","timestamp":1648555435000},"page":"e248358","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Antisynthetase syndrome sine myositis presenting as severe acute respiratory failure"],"prefix":"10.1136","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8015-4039","authenticated-orcid":false,"given":"Christian","family":"Archer","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine, Kettering General Hospital, Kettering, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khola","family":"Nazim","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Kettering General Hospital, Kettering, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selva","family":"Panchatsharam","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Kettering General Hospital, Kettering, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"2025082709240858000_15.3.e248358.1","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.21037\/jtd.2019.04.84","article-title":"Prognosis of patients with acute respiratory failure and prolonged intensive care unit stay","volume":"11","author":"Lai","year":"2019","journal-title":"J Thorac Dis"},{"key":"2025082709240858000_15.3.e248358.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"2025082709240858000_15.3.e248358.3","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000057906.89552.8F"},{"key":"2025082709240858000_15.3.e248358.4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.01942001"},{"key":"2025082709240858000_15.3.e248358.5","unstructured":"Antoine M , Milka M . 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